(S_a)-4',6''-dimethyl-[1,1':3',1'':3'',1'''-quaterphenyl]-2',2''-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S_a)-4',6''-dimethyl-[1,1':3',1'':3'',1'''-quaterphenyl]-2',2''-diamine
• 英文别名: (S)-2',2''-diamino-6',6''-dimethyl-m-quaterphenyl；2-(2-Amino-6-methyl-3-phenylphenyl)-3-methyl-6-phenylaniline
• 化学式: C₂₆H₂₄N₂
• 分子量: 364.49
• InChiKey: UNCBCPJDOWDGTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S_a)-N,N'-(4',6''-dimethyl-[1,1':3',1'':3'',1'''-quaterphenyl]-2',2''-diyl)diacetamide 在 氢氧化钾 、 水 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以94%的产率得到(S_a)-4',6''-dimethyl-[1,1':3',1'':3'',1'''-quaterphenyl]-2',2''-diamine
  参考文献：
  名称：

  Steric Modulation of Chiral Biaryl Diamines via Pd-Catalyzed Directed C−H Arylation

  摘要：

  Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis.

  DOI：

  10.1021/jo802632v

文献信息

• Steric Modulation of Chiral Biaryl Diamines via Pd-Catalyzed Directed C−H Arylation
  作者：Christopher C. Scarborough、Richard I. McDonald、Caroline Hartmann、Graham T. Sazama、Ana Bergant、Shannon S. Stahl

  DOI：10.1021/jo802632v

  日期：2009.3.20

  Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis.