5-[2-(Biphenyl-2-yloxy)ethyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[2-(Biphenyl-2-yloxy)ethyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
• 英文别名: 6-[2-(2-phenylphenoxy)ethyl]-4,5,6,7-tetrahydro-1H-benzimidazole;hydrochloride
• 化学式: C₂₁H₂₂N₂O*ClH
• 分子量: 354.879
• InChiKey: AAPWSGKLFZOVPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(1(3)-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)ethanol 、 邻苯基苯酚 生成 5-[2-(Biphenyl-2-yloxy)ethyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Imidazo heterocyclic compounds
  申请人：——

  公开号：US20010049385A1

  公开（公告）日：2001-12-06

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的咪唑杂环化合物类，包括它们的药物组合物以及它们在治疗和/或预防与组胺H3受体相关的疾病和紊乱中的应用。更具体地说，这些化合物对于治疗和/或预防需要与组胺H3受体相互作用有益的疾病和紊乱是有用的。
• CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS
  申请人：NOVO NORDISK A/S

  公开号：EP1268483A1

  公开（公告）日：2003-01-02
• US6610721B2
  申请人：——

  公开号：US6610721B2

  公开（公告）日：2003-08-26
• [EN] CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS<br/>[FR] IMIDAZOLES CONDENSES COMME LIGANDS DU RECEPTEUR H3 DE L'HISTAMINE
  申请人：NOVO NORDISK AS

  公开号：WO2001068651A1

  公开（公告）日：2001-09-20

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.