N-(3-methylsalicyloyl)-8-aminocaprylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-methylsalicyloyl)-8-aminocaprylic acid
• 英文别名: 8-[(2-hydroxy-3-methylbenzoyl)amino]octanoic acid
• 化学式: C₁₆H₂₃NO₄
• 分子量: 293.363
• InChiKey: AARPAILLCGTSSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-氨基辛酸 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 N-(3-methylsalicyloyl)-8-aminocaprylic acid
  参考文献：
  名称：

  Synthesis and Evaluation of Compounds That Facilitate the Gastrointestinal Absorption of Heparin

  摘要：

  A family of novel compounds (delivery agents) that promote the gastrointestinal absorption of USP heparin in rats and primates has been discovered. The delivery agents in combination with heparin were administered either orally or intracolonically in an aqueous propylene glycol solution and caused dramatic increases in both plasma heparin concentrations (anti-Factor Xa) and clotting times (APTT). Using one of the most effective delivery agents in this series, an estimated relative bioavailability of 8% can be achieved following oral administration to cynomolgus monkeys. To establish a correlation between the in vivo data and an in vitro parameter, immobilized artificial membrane (IAM) chromatography was performed. Log relative k' values were correlated to the efficiency of oral heparin delivery.

  DOI：

  10.1021/jm970811m

文献信息

• COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
  申请人：Sarubbi Donald J.

  公开号：US20090324540A1

  公开（公告）日：2009-12-31

  Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

  本发明提供了用于传递活性剂的载体化合物和组合物。同时还提供了其治疗方法和制备方法。
• Method of preparing salicyloylamino acids
  申请人：Emisphere Technologies, Inc.

  公开号：US05962710A1

  公开（公告）日：1999-10-05

  A method for preparing salicyloylamino acids is provided. An oligosalicylate and an amino acid are reacted to yield the salicyloylamino acid.

  提供了一种制备水杨酰胺基酸的方法。通过反应寡聚水杨酸盐和氨基酸，得到水杨酰胺基酸。
• Method for administering GLP-1 molecules
  申请人：Emisphere Technologies, Inc.

  公开号：EP2409569A2

  公开（公告）日：2012-01-25

  The invention encompasses formulations that demonstrate the feasibility of oral absorption comprising GLP-1 compounds and specified delivery agents.

  本发明包括能证明口服吸收 GLP-1 化合物和特定给药剂可行性的制剂。
• METHOD FOR ADMINISTERING GLP-1 MOLECULES
  申请人：Emisphere Technologies, Inc.

  公开号：EP1478233B1

  公开（公告）日：2016-11-09
• EP2409569B1
  申请人：——

  公开号：EP2409569B1

  公开（公告）日：2017-08-16