三(2,3-二甲基苯基)亚磷酸酯 | 102937-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 三(2,3-二甲基苯基)亚磷酸酯
• 英文名称: Tris(2,3-dimethylphenyl) phosphite
• CAS: 102937-84-8
• 化学式: C₂₄H₂₇O₃P
• 分子量: 394.45
• InChiKey: JBXUHJUOOSISGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氨基甲酸苄酯 、 三(2,3-二甲基苯基)亚磷酸酯 、 异戊醛 在 溶剂黄146 作用下， 生成 benzyl N-[1-bis(2,3-dimethylphenoxy)phosphoryl-3-methylbutyl]carbamate
  参考文献：
  名称：

  Simple phosphonic inhibitors of human neutrophil elastase

  摘要：

  Herein, we describe the synthesis and resulting activity of a complex series of alpha-aminophosphonate diaryl esters as irreversible human neutrophil elastase inhibitors and their selectivity preference for human neutrophil elastase over several other serine proteases such as porcine pancreatic elastase, trypsin, and chymotrypsin. We synthesized and examined the inhibitory potency of several new simple Cbz-protected alpha-aminoalkylphosphonate diaryl esters that yielded several new HNE inhibitors, where one of the obtained compounds Cbz-Val(P)(OC6H4-4-COOMe)(2) displayed an apparent second-order inhibition value at 33,015 M (1) s (1). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.083
• 作为产物：
  描述：

  二甲酚 在 三氯化磷 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 三(2,3-二甲基苯基)亚磷酸酯
  参考文献：
  名称：

  Simple phosphonic inhibitors of human neutrophil elastase

  摘要：

  Herein, we describe the synthesis and resulting activity of a complex series of alpha-aminophosphonate diaryl esters as irreversible human neutrophil elastase inhibitors and their selectivity preference for human neutrophil elastase over several other serine proteases such as porcine pancreatic elastase, trypsin, and chymotrypsin. We synthesized and examined the inhibitory potency of several new simple Cbz-protected alpha-aminoalkylphosphonate diaryl esters that yielded several new HNE inhibitors, where one of the obtained compounds Cbz-Val(P)(OC6H4-4-COOMe)(2) displayed an apparent second-order inhibition value at 33,015 M (1) s (1). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.083

文献信息

• DIARYL ALKYLPHOSPHONATES AND METHODS FOR PREPARING SAME
  申请人：Hadjikyriacou Savvas

  公开号：US20090203942A1

  公开（公告）日：2009-08-13

  A method for preparing substantially pure optionally substituted diaryl alkylphosphonates from an optionally substituted triarylphosphite and an optionally substituted trialkylphosphite or an optionally substituted alkanol under special reaction conditions is described.

  描述了一种从可选取代的三芳基膦酸酯和可选取代的三烷基膦酸酯或可选取代的烷醇在特殊反应条件下制备基本纯的可选取代的二芳基烷基膦酸酯的方法。
• Latent mercaptans as multi-functional additives for halogen-containing polymer compositions
  申请人：——

  公开号：US20030216493A1

  公开（公告）日：2003-11-20

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含有通常与巯基相关联的刺激性气味，在加工过程中通过潜在（即被阻断的）巯基的降解产物（包括自由巯基）来保护。降解的其他产物被认为包括阻断基的碳正离子，其通过电子亏损由几个基团共享的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同作用于金属基热稳定剂，如金属盐和有机金属稳定剂，如有机锡羧酸盐和巯基化合物在聚合物组合物中的活性。通过少量潜在巯基掩盖含有主要巯基热稳定剂的卤化聚合物组合物的气味。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩合，并将粗产品与含巯基的化合物进一步缩合，可以制备高效的热稳定剂。
• LATENT MERCAPTANS AS MULTI-FUNCTIONAL ADDITIVES FOR HALOGEN-CONTAINING POLYMER COMPOSITIONS
  申请人：——

  公开号：US20020068780A1

  公开（公告）日：2002-06-06

  Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan. The latent mercaptans also serve as intermediates in the preparation of anti-oxidants, anti-microbial agents, photostabilizers, and primary heat stabilizers. Highly effective heat stabilizers are prepared by the condensation of formaldehyde and a para-phenol and further condensation of the crude product with a mercapto-containing compound.

  含卤素的聚合物组合物包括一种潜在的巯基含量热稳定剂组合物，该组合物基本上不含通常与巯基相关的刺激性气味，通过潜在（即阻塞）巯基的降解产物，包括自由巯基，来保护加工过程中的聚合物组合物。降解的其他产物被认为包括阻塞基的碳正离子，其由多个基团共享电子亏损的分子结构稳定。潜在巯基可以是唯一的热稳定剂添加剂，但在加工过程中释放的自由巯基也可以协同金属基热稳定剂（如金属盐）和有机金属稳定剂（如有机锡羧酸盐和巯基化合物）的活性。在卤化聚合物组合物中，主要巯基含量热稳定剂的气味被少量潜在巯基掩盖。潜在巯基还可用作抗氧化剂、抗微生物剂、光稳定剂和主要热稳定剂的制备中间体。通过甲醛和对苯酚的缩聚，并将粗品与含巯基化合物进一步缩聚，制备出高效的热稳定剂。
• Lubricant and fuel compositions containing hydroxy carboxylic acid and hydroxy polycarboxylic acid esters
  申请人：Migdal A. Cyril

  公开号：US20050198894A1

  公开（公告）日：2005-09-15

  Disclosed herein is a composition comprising: (A) a lubricant or a hydrocarbon fuel; (B) at least one hydroxy carboxylic acid ester or hydroxy polycarboxylic acid ester having the generic formula defined herein; and (C) at least one phosphorus-containing additive.

  本文揭示了一种组合物，包括：（A）润滑剂或烃类燃料；（B）至少一种具有定义于此处的通用公式的羟基羧酸酯或羟基多羧酸酯；以及（C）至少一种含磷添加剂。
• Process of producing aldehydes
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20040054236A1

  公开（公告）日：2004-03-18

  A process of producing aldehydes in a continuous hydroformylation process of continuously reacting an olefinic unsaturated compound with carbon monoxide and hydrogen in the presence of a rhodium-phosphite based complex catalyst and continuously separating at least one component from a reaction product, the process being characterized in that at least a part of an aldehyde product and water are taken out as a mixed vapor flow from a catalyst-existent region in the process, and at least a part thereof is fed outside the catalyst-existent region as it stands as the vapor or as a condensate after cooling, to reduce the water concentration within the catalyst-existent region, whereby decomposition of phosphite ligands in the hydroformylation process of olefins is suppressed.

  一种连续加氢甲酰化过程的生产醛的方法，该方法连续反应烯烃不饱和化合物与一氧化碳和氢气，在铑膦酸酯类复合催化剂的存在下进行，并连续从反应产物中分离至少一种组分，其特征在于，至少部分醛产品和水从催化剂存在区域作为混合气体流出，其中至少部分作为蒸汽或冷却后的冷凝物保持原状流出到催化剂存在区域之外，以降低催化剂存在区域内的水浓度，从而抑制烯烃加氢甲酰化过程中膦酸酯配体的分解。