7-[[(1S,4aS,6R,8aS)-6-hydroxy-2,5,5,8a-tetramethyl-4-oxo-4a,6,7,8-tetrahydro-1H-naphthalen-1-yl]methoxy]chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[[(1S,4aS,6R,8aS)-6-hydroxy-2,5,5,8a-tetramethyl-4-oxo-4a,6,7,8-tetrahydro-1H-naphthalen-1-yl]methoxy]chromen-2-one
• 化学式: C₂₄H₂₈O₅
• 分子量: 396.5
• InChiKey: HIQLOIOGTRDMIW-ZUAOHOGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITION FOR TREATING INFLUENZA A (H1N1) VIRUS AND A PREPARATION METHOD THEREFOR
  申请人：KAOHSIUNG MEDICAL UNIVERSITY

  公开号：US20130245114A1

  公开（公告）日：2013-09-19

  New pharmaceutical compositions extracted from Ferula assa - foetida are confirmed to effectively treat influenza A (H 1 N 1 ) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa - foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.
• US8815949B2
  申请人：——

  公开号：US8815949B2

  公开（公告）日：2014-08-26