3-[3-(cyclopentyloxy)-4-methoxybenzyl]-8-[1,1-dimethyl-2-(thiophen-2-yloxy)ethyl]-3H-purin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-[3-(cyclopentyloxy)-4-methoxybenzyl]-8-[1,1-dimethyl-2-(thiophen-2-yloxy)ethyl]-3H-purin-6-amine
• 英文别名: 3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-8-[2-(thiophen-2-ylmethoxy)propan-2-yl]purin-6-amine
• 化学式: C₂₆H₃₁N₅O₃S
• 分子量: 493.63
• InChiKey: ACFUUKIQWRKQRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.25
• 重原子数：
  35.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  97.31
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  4-(氯甲基)-2-(环戊氧基)-1-甲氧基苯 在 potassium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 53.0h， 生成 3-[3-(cyclopentyloxy)-4-methoxybenzyl]-8-[1,1-dimethyl-2-(thiophen-2-yloxy)ethyl]-3H-purin-6-amine
  参考文献：
  名称：

  8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors

  摘要：

  3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine V11294 (1) has been identified as a lead structure, which selectively inhibits human lung PDE4 (436 nM) and is also active in a number of in vitro and in vivo models of inflammation. Here we describe the synthesis and pharmacology of a series of highly potent 8-[(benzyloxy)methyl]-substituted analogues, with potencies in the range 10-300 nM. In addition, several compounds showed interesting PDE4 subtype specificities, for example, the 3-thienyl derivative 5v, which showed 6-10 nM potency at PDE4B, D3, and D5 and a 20- to 200-fold selectivity over A and D2, respectively.

  DOI：

  10.1021/jm030603w

文献信息

• US6413975B1
  申请人：——

  公开号：US6413975B1

  公开（公告）日：2002-07-02
• 8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors
  作者：John W. F. Whitehead、Gary P. Lee、Parviz Gharagozloo、Peter Hofer、André Gehrig、Peter Wintergerst、Donald Smyth、William McCoull、Mohamed Hachicha、Aniket Patel、Donald J. Kyle

  DOI：10.1021/jm030603w

  日期：2005.2.1

  3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine V11294 (1) has been identified as a lead structure, which selectively inhibits human lung PDE4 (436 nM) and is also active in a number of in vitro and in vivo models of inflammation. Here we describe the synthesis and pharmacology of a series of highly potent 8-[(benzyloxy)methyl]-substituted analogues, with potencies in the range 10-300 nM. In addition, several compounds showed interesting PDE4 subtype specificities, for example, the 3-thienyl derivative 5v, which showed 6-10 nM potency at PDE4B, D3, and D5 and a 20- to 200-fold selectivity over A and D2, respectively.