4-Hydroxy-thiobenzamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxy-thiobenzamine
• 英文别名: 4-Hydroxysulfanylaniline
• 化学式: C₆H₇NOS
• mdl: MFCD19207311
• 分子量: 141.194
• InChiKey: ACYUTMJGPYKZPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[(4-硝基苯基)二硫烷基]苯胺 在 氢氧化钾 作用下， 以 叔丁醇 为溶剂， 生成 4-nitro-thiophenol potassium salt 、 4-Hydroxy-thiobenzamine
  参考文献：
  名称：

  Happer,D.A.R. et al., Australian Journal of Chemistry, 1973, vol. 26, p. 121 - 134

  摘要：

  DOI：

文献信息

• Processes and intermediates useful in preparing beta3-adrenergic receptor agonists
  申请人：——

  公开号：US20030199046A1

  公开（公告）日：2003-10-23

  The present invention provides processes useful in the preparation of certain &bgr; 3 -adrenergic receptor agonists of the structural formula 1 the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.

  本发明提供了在制备特定的β3-肾上腺素受体激动剂的过程中有用的方法，其结构式如下：其中HET如本文所述。该发明还提供了在制备这类激动剂中有用的中间体，以及在生产这类中间体中有用的过程。
• [EN] SYNTHESIS OF ACETAL COMPOUNDS USING ZWITTERIONIC CATALYSTS<br/>[FR] SYNTHÈSE DE COMPOSÉS ACÉTAL À L'AIDE DE CATALYSEURS ZWITTERIONIQUES
  申请人：AGFA GRAPHICS NV

  公开号：WO2015062935A1

  公开（公告）日：2015-05-07

  A process for the preparation of optionally asymmetric acetal compounds, comprising reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that the basic nitrogen on sulfonic acid molar ratio is 1 over 1.

  一种制备可选择性不对称缩醛化合物的方法，包括在带有至少一个碱性氮结构基团和至少一个磺酸基团的偶极催化剂存在下，将含有羟基的化合物与乙烯基醚化合物反应，但碱性氮和磺酸的摩尔比为1比1。
• Processes and intermediates useful in preparing beta-3-adrenergic receptor agonists
  申请人：Pfizer Inc

  公开号：US20040077871A1

  公开（公告）日：2004-04-22

  The present invention provides processes useful in the preparation of certain &bgr; 3 -adrenergic receptor agonists of the structural formula 1 the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.

  本发明提供了在制备某些结构式1的β3-肾上腺素受体激动剂中有用的过程，其药物可接受的盐以及所述药物可接受的盐的水合物，其中HET如本文所述。本发明还提供了在制备这种激动剂中有用的中间体，以及在生产这种中间体中有用的过程。
• Derivatized 3-styryl-cephalosporins
  申请人：Gladius Pharmaceuticals Corporation

  公开号：US11028103B2

  公开（公告）日：2021-06-08

  Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.

  广谱β-内酰胺酶抑制剂。某些抑制剂除了抑制β-内酰胺酶外，还具有很强的抗生素活性。本发明的化合物设计成在β-内酰胺环裂解时产生活性分子，可使β-内酰胺酶失活。本发明还提供了制造β-内酰胺酶抑制剂的方法和具有这种抑制作用的β-内酰胺类抗生素。此外，还提供了用于治疗或预防细菌感染的药物组合物以及治疗此类感染的方法。
• PIGMENT COMPOSITIONS WITH MODIFIED ATRP COPOLYMER DISPERSANTS
  申请人：BASF SE

  公开号：EP1465935B1

  公开（公告）日：2016-09-07