ethyl 2-hydroxy-2-phenyl-2-p-tolylacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-hydroxy-2-phenyl-2-p-tolylacetate
• 英文别名: Ethyl 2-hydroxy-2-phenyl-2-(p-tolyl)acetate；ethyl 2-hydroxy-2-(4-methylphenyl)-2-phenylacetate
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.328
• InChiKey: ADDIWJJEKICZLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲酰甲酸乙酯 、 4-甲苯硼酸 在 phosphite-based type I palladacycle potassium phosphate 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以68%的产率得到ethyl 2-hydroxy-2-phenyl-2-p-tolylacetate
  参考文献：
  名称：

  Phosphinite- and phosphite-based type I palladacycles as highly active catalysts for addition reactions of arylboronic acids with aldehydes, α,β-unsaturated ketones, α-ketoesters, and aldimines

  摘要：

  Phosphinite- and phosphite-based type I palladacycle-catalyzed additions of arylboronic acids with aldehydes, alpha,beta-unsaturated ketones, alpha-ketoesters, and aldimines are described. Our study showed that readily available phosphinite- and phosphite-based type I palladacycles could possess higher catalytic activity than phosphine-based palladacycles and were highly active, practical catalysts. Our study may pave the road for development of optically active phosphinite- and phosphite-based palladacycles for asymmetric catalysis. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.119

文献信息

• Phosphinite- and phosphite-based type I palladacycles as highly active catalysts for addition reactions of arylboronic acids with aldehydes, α,β-unsaturated ketones, α-ketoesters, and aldimines
  作者：Ping He、Yong Lu、Qiao-Sheng Hu

  DOI：10.1016/j.tetlet.2007.05.119

  日期：2007.7

  Phosphinite- and phosphite-based type I palladacycle-catalyzed additions of arylboronic acids with aldehydes, alpha,beta-unsaturated ketones, alpha-ketoesters, and aldimines are described. Our study showed that readily available phosphinite- and phosphite-based type I palladacycles could possess higher catalytic activity than phosphine-based palladacycles and were highly active, practical catalysts. Our study may pave the road for development of optically active phosphinite- and phosphite-based palladacycles for asymmetric catalysis. (C) 2007 Elsevier Ltd. All rights reserved.