5-(4-methylphenyl)-3-hydroxy-4-aminopent-1-ene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-methylphenyl)-3-hydroxy-4-aminopent-1-ene
• 英文别名: 4-Amino-5-(4-methylphenyl)pent-1-en-3-ol
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: ADHJRRLHSCMZNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 magnesium,1-methanidyl-4-methylbenzene,bromide 、 丙烯醛 以60%的产率得到5-(4-methylphenyl)-3-hydroxy-4-aminopent-1-ene
  参考文献：
  名称：

  A Convenient One-Pot Synthesis of 1,2-Aminoalcohols

  摘要：

  We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.

  DOI：

  10.1080/00397919808004848

文献信息

• A Convenient One-Pot Synthesis of 1,2-Aminoalcohols
  作者：J. Howarth、D. G. Lloyd、P. McCormac

  DOI：10.1080/00397919808004848

  日期：1998.8

  We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.