N²-tert-butyl-2-(4-nitrophenyl)-N¹,N¹-diphenyl-1,1,2-ethanetricarboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N²-tert-butyl-2-(4-nitrophenyl)-N¹,N¹-diphenyl-1,1,2-ethanetricarboxamide
• 英文别名: 2-N-tert-butyl-2-(4-nitrophenyl)-1-N,1-N-diphenylethane-1,1,2-tricarboxamide
• 化学式: C₂₇H₂₈N₄O₅
• 分子量: 488.543
• InChiKey: ADUWEZHVZIYRLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 在 copper(I) iodide 作用下， 以 乙醇 为溶剂， 反应 5.5h， 生成 N²-tert-butyl-2-(4-nitrophenyl)-N¹,N¹-diphenyl-1,1,2-ethanetricarboxamide
  参考文献：
  名称：

  Pseudo five-component process for the synthesis of functionalized tricarboxamides using CuI nanoparticles as reusable catalyst

  摘要：

  An efficient and multicomponent method has been developed for the synthesis of functionalized tricarboxamides at room temperature using CuI nanoparticles as catalyst. This method involved five-component coupling reactions of Meldrum's acid, isocyanides with aromatic aldehydes and amines at room temperature. Atom economy, wide range of products, excellent yields in short time and mild reaction conditions are some of the important features of this protocol. Notably, this catalyst could be recycled and reused for several times without significantly decreasing the catalytic activity. (C) 2013 Javad Safaei-Ghomi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.01.049

文献信息

• Microwave-assisted synthesis of triamide derivatives via a <i>pseudo</i> five-component one-pot reaction
  作者：Zohreh Shirdel、Mohammad Reza Hosseini-Tabatabaei

  DOI：10.1080/15533174.2016.1216454

  日期：2017.6.3

  The reaction between Meldrum's acid and aryl aldehydes with alkyl isocyanides in the presence of two equivalents of aniline in microwave conditions provided a simple and efficient one-pot route for the synthesis of triamide derivatives in good yields. The present method does not involve any hazardous organic solvent. Therefore, this procedure could be classified as green chemistry.

  在微波条件下，在两当量苯胺存在下，Meldrum的酸和芳基醛与烷基异氰化物之间的反应为高收率的三酰胺衍生物的合成提供了简单有效的一锅法。本方法不涉及任何有害的有机溶剂。因此，该程序可以归类为绿色化学。
• An Efficient One-Pot Synthesis of Triamides and Amidodiesters
  作者：A. Shaabani、M. B. Teimouri、H. R. Bijanzadeh

  DOI：10.1023/b:rujo.0000045188.81414.1d

  日期：2004.7

  An efficient one-pot procedure has been proposed for the synthesis of compounds containing three carboxamide groups or one carboxamide and two ester groups. The procedure is based on three-component condensation of alkyl isocyanides with 5-alkylidene- or 5-arylmethylene-substituted Meldrum's acids in the presence of such nucleophiles as phenols and amines.
• Pseudo five-component process for the synthesis of functionalized tricarboxamides using CuI nanoparticles as reusable catalyst
  作者：Abolfazl Ziarati、Javad Safaei-Ghomi、Sahar Rohani

  DOI：10.1016/j.cclet.2013.01.049

  日期：2013.3

  An efficient and multicomponent method has been developed for the synthesis of functionalized tricarboxamides at room temperature using CuI nanoparticles as catalyst. This method involved five-component coupling reactions of Meldrum's acid, isocyanides with aromatic aldehydes and amines at room temperature. Atom economy, wide range of products, excellent yields in short time and mild reaction conditions are some of the important features of this protocol. Notably, this catalyst could be recycled and reused for several times without significantly decreasing the catalytic activity. (C) 2013 Javad Safaei-Ghomi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.