(4RS,5SR,7RS) 2-aza-4-hexylsulfanyl-5-butyl-bicyclo[3.2.0]heptan-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (4RS,5SR,7RS) 2-aza-4-hexylsulfanyl-5-butyl-bicyclo[3.2.0]heptan-1,3-dione
• 英文别名: 7-Butyl-1-hexylsulfanyl-3-azabicyclo[3.2.0]heptane-2,4-dione；7-butyl-1-hexylsulfanyl-3-azabicyclo[3.2.0]heptane-2,4-dione
• 化学式: C₁₆H₂₇NO₂S
• 分子量: 297.462
• InChiKey: AEIZIGRHPAMUBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-己烯 、 3-hexylsulfanylmaleimide 以 乙腈 为溶剂， 反应 0.08h， 以12%的产率得到1-butyl-4-hexylsulfanyl-1,7-dihydro-2H-azepine-3,6-dione
  参考文献：
  名称：

  Reversible covalent linkage of functional molecules

  摘要：

  本发明涉及使用含有式(I)的基团的化合物作为将具有式F1的第一功能基团的化合物R1-H与具有式F2的第二功能基团连接的试剂 其中X、X'、Y、R1、F1和F2如本文所定义。本发明还提供相关的工艺和产品。本发明适用于制备功能共轭化合物，特别是至少一种组分分子携带硫醇基团的共轭物。

  公开号：

  US09295729B2

文献信息

• [EN] FUNCTIONALISATION OF SOLID SUBSTRATES<br/>[FR] FONCTIONNALISATION DE SUBSTRATS SOLIDES
  申请人：UCL BUSINESS PLC

  公开号：WO2011018613A1

  公开（公告）日：2011-02-17

  The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X' and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis.
• [EN] REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES<br/>[FR] LIAISON COLAVENTE RÉVERSIBLE DE MOLÉCULES FONCTIONNELLES
  申请人：UCL BUSINESS PLC

  公开号：WO2011018611A1

  公开（公告）日：2011-02-17

  The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1-H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X', Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
• Reversible covalent linkage of functional molecules
  申请人：Smith Mark

  公开号：US09295729B2

  公开（公告）日：2016-03-29

  The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

  本发明涉及使用含有式(I)的基团的化合物作为将具有式F1的第一功能基团的化合物R1-H与具有式F2的第二功能基团连接的试剂 其中X、X'、Y、R1、F1和F2如本文所定义。本发明还提供相关的工艺和产品。本发明适用于制备功能共轭化合物，特别是至少一种组分分子携带硫醇基团的共轭物。