2-(γ-Aminopropyl)-2-(β-aminoethyl)-adamantan

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(γ-Aminopropyl)-2-(β-aminoethyl)-adamantan
• 英文别名: 3-[2-(2-Aminoethyl)-2-adamantyl]propan-1-amine
• 化学式: C₁₅H₂₈N₂
• 分子量: 236.401
• InChiKey: AHELTBNQVSEOAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2'-Oxoadamantan-spiro-3'-tetrahydrofuran 在 platinum(IV) oxide 盐酸 、 lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 、 乙醇 、 乙二醇甲醚 为溶剂， 生成 2-(γ-Aminopropyl)-2-(β-aminoethyl)-adamantan
  参考文献：
  名称：

  金刚烷螺化合物的合成和抗病毒活性。2。

  摘要：

  DOI：

  10.1021/jm00272a004

文献信息

• [EN] 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION<br/>[FR] 2-ADAMANTYLALKYLAMINES ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES GENERALEMENT ASSOCIES A DES ANOMALIES DE LA TRANSMISSION GLUTAMATERGIQUE
  申请人：VERNALIS RES LTD

  公开号：WO2003064372A1

  公开（公告）日：2003-08-07

  The use of a compound of formula (1) wherein X is oxygen or (CR11R12)n; n is 0 or 1; R1, R2, R3, R4, R5, R6, R7, R8, R11 and R12 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s) thereof may together form a 3, 4, 5, 6, 7 or 8-membered ring containing 0, 1 or 2 heteroatom(s); R9 is selected from alkyl, aryl and non-aromatic heterocyclic groups; and R10 is selected from hydrogen, halogen, alkyl, aryl and non-aromatic heterocyclic groups; and pharmaceutically acceptable salts and prodrugs thereof, in therapy and the manufacture of amedicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission, particularly Alzheimer's disease, ischaemic stroke, haemorrhagic stroke, epilepsy, multiple sclerosis, pain, drug-induced optic neuritis, myelopathy, glaucoma, peripheral neuropathy, ischaemic retinopathy, traumatic brain or spinal injury, Parkinson's Disease and Huntington's Disease; and novel compounds of formula (1) per se.
• Synthesis and antiviral activities of adamantane spiro compounds. 2
  作者：R. Van Hes、A. Smit、T. Kralt、A. Peters

  DOI：10.1021/jm00272a004

  日期：1972.2