1-(4,5,6,7-tetrahydro-1-benzothiophen-7-yl)piperidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(4,5,6,7-tetrahydro-1-benzothiophen-7-yl)piperidine
• 化学式: C₁₃H₁₉NS
• 分子量: 221.367
• InChiKey: AIORKFSJOBBMAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,5,6,7-四氢-1-苯并噻吩 在 cerium (IV) sulfate 、 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 124.0h， 生成 1-(4,5,6,7-tetrahydro-1-benzothiophen-7-yl)piperidine
  参考文献：
  名称：

  New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes

  摘要：

  4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro-benzothiophen-4-ylamines and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH. radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80011-7

文献信息

• New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes
  作者：Isoline Cauquil-Caubère、Jean-Marc Kamenka

  DOI：10.1016/s0223-5234(99)80011-7

  日期：1998.11

  4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro-benzothiophen-4-ylamines and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH. radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate. (C) Elsevier, Paris.