三十烷酰氯 | 72106-52-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 三十烷酰氯
• 英文名称: triacontanoyl chloride
• 英文别名: melissoyl chloride
• CAS: 72106-52-6
• 化学式: C₃₀H₅₉ClO
• 分子量: 471.251
• InChiKey: GQEACALFLNZJGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.9
• 重原子数：
  32
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三十烷酰氯 、 DL-carnitine isopropyl ester 以 氯仿 为溶剂， 反应 4.0h， 以59%的产率得到(3-Isopropoxycarbonyl-2-triacontanoyloxy-propyl)-trimethyl-ammonium; chloride
  参考文献：
  名称：

  The Synthesis, and Structure-activity Relationships of some Long Chain Acyl Carnitine Esters on the Coronary Circulation of the Rat Isolated Heart

  摘要：

  摘要：本文介绍了合成肉碱异丙酯和一系列脂肪酸衍生物（脂肪酸链长为C8-C30）的过程。这些化合物的脉冲剂量（0.03-300纳摩尔）在大鼠离体心脏中显示冠状动脉扩张活性。从C8到C16脂肪酸链长度的增加导致了扩张剂效力的增加。C20化合物表现出持久的扩张作用。将脂肪酸链长度增加到C30与小的扩张反应相伴随，先前有血管收缩的现象。

  DOI：

  10.1111/j.2042-7158.1991.tb03553.x

文献信息

• Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4′-<i>epi</i>-C-Glycoside of KRN7000
  作者：Ya-Jen Chang、Yi-Chen Hsuan、Alan Chuan-Ying Lai、Yun-Chiann Han、Duen-Ren Hou

  DOI：10.1021/acs.orglett.6b00090

  日期：2016.2.19

  A new immunostimulant, the 4′-epimer of α-C-GalCer, was synthesized from a C2-symmetric dienediol and α-C-allyl galactoside. The intramolecular aziridination and the following reductive ring opening provided the core of the aliphatic amino alcohol with excellent regio- and stereocontrol. The new immunostimulants 3d and 3e gave a better polarized Th1-type cytokine response in murine NKT cells than the

  由C 2对称二烯二醇和α-C-烯丙基半乳糖苷合成了一种新的免疫刺激剂，α-C-GalCer的4'-末端。分子内的叠氮化和随后的还原性开环为脂族氨基醇的核提供了出色的区域和立体控制。与基准α-C-GalCer相比，新的免疫刺激剂3d和3e在鼠NKT细胞中产生了更好的极化Th1型细胞因子应答。
• Synthesis and biological activities of N-acetyl-1-thiomuramoyl-l-alanyl-d-isoglutamine and some of its lipophilic derivatives
  作者：Akira Hasegawa、Yuichi Hioki、Makoto Kiso、Hiroyuki Okumura、Ichiro Azuma

  DOI：10.1016/0008-6215(83)88476-6

  日期：1983.11

  yl-D-isoglutamine derivatives, which were converted into the desired, lipophilic 1-thiomuramoyl dipeptides by cleavage of the isopropylidene group. Condensation of 11 with the alkyl bromides yielded the 1-S-alkyl derivatives, which were also converted, via O-deisopropylidenation and de-esterification, into the corresponding 1-S-alkylmuramoyl dipeptides. The biological activities were examined in guinea-pigs

  由苄基2-乙酰氨基-2-脱氧-4,6-O-异亚丙基-3-O- [D-1-（甲氧基羰基）合成N-乙酰基-1-硫代村酰基-L-丙氨酰基-D-异谷氨酰胺和一些亲脂性类似物）乙基]-α-D-吡喃葡萄糖苷（1）。氧化衍生自1的2，进行O-脱苯甲酰化，得到2-乙酰氨基-2-脱氧-4,6-O-异亚丙基-3-O- [D-1-（甲氧羰基）乙基] -D-吡喃葡萄糖（3） 。由四氯化碳和三（二甲基氨基）膦的作用由3形成的烷氧基-三（二甲基氨基）phosph氯化物（4）与硫代乙酸钾的缩合得到2-乙酰胺基-1-S-乙酰基-2-脱氧-4 ，6-O-异亚丙基-3-O- [D-1-（甲氧羰基）乙基] -1-硫代-β-D-吡喃葡萄糖（8）。将通过水解和随后的S-乙酰化反应从8中获得的酸9与L-丙氨酰-D-异谷氨酰胺的甲酯偶联，得到N- [2-O-（2-2-乙酰胺基-1-S-乙酰基-2] 3-二甲氧基-4，6-O-异亚丙基-
• POLYMER
  申请人：Sumitomo Chemical Company, Ltd.

  公开号：EP3235836A1

  公开（公告）日：2017-10-25

  Provided is a polymer that is capable of affording a heat storage material superior in humidity permeability and shape retention after phase transition and that is superior in molding processability, namely, a polymer including constitutional units (A) derived from ethylene, constitutional units (B) represented by a specified formula, and optionally including constitutional units (C) represented by a specified formula, wherein where the total number of the units (A), the units (B), and the units (C) is 100%, the number of the units (A) accounts for 70% to 99%, the total number of the units (B) and the units (C) accounts for 1% by weight to 30% by weight, and where the total number of the units (B) and the units (C) is 100%, the number of the units (B) accounts for 1% to 100% and the number of the units (C) accounts for 0% to 99%.

  本发明提供了一种聚合物，该聚合物能够提供一种在相变后湿度渗透性和形状保持性方面更优越且在成型加工性方面更优越的蓄热材料，即一种包括由乙烯衍生的组成单元（A）、由指定式表示的组成单元（B）以及可选地包括由指定式表示的组成单元（C）的聚合物、其中，当单元（A）、单元（B）和单元（C）的总数量为 100%时，单元（A）的数量占 70%至 99%，单元（B）和单元（C）的总数量占 1%至 30%（按重量计），而当单元（B）和单元（C）的总数量为 100%时，单元（B）的数量占 1%至 100%，单元（C）的数量占 0%至 99%。
• RESIN PRODUCT AND MEDICINAL COMPONENT DISPENSING DEVICE
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3385332A1

  公开（公告）日：2018-10-10

  The present invention provides a resin product comprising: an active ingredient; a thermoplastic resin (2) having a melting enthalpy (ΔH) of 30 J/g or more, as observed by differential scanning calorimetry within a temperature range of 10°C or more and less than 60°C; and a thermoplastic resin (3) having a storage elastic modulus E' at 60°C of 5.0 × 105 Pa or more, as determined by dynamic viscoelasticity measurement at a frequency of 10 Hz. The present invention also provides a molded article comprising the resin product and a device for sustained-release of an active ingredient comprising a component consisting of the resin product.

  本发明提供了一种树脂产品，包括：活性成分；热塑性树脂（2），其熔化焓（ΔH）为 30 J/g 或更高，通过差示扫描量热法在 10°C 或更高且低于 60°C 的温度范围内进行观察；以及热塑性树脂（3），其在 60°C 时的存储弹性模量 E' 为 5.0 × 105 Pa 或更高，通过频率为 10 Hz 的动态粘弹性测量进行测定。本发明还提供了一种由该树脂产品组成的模塑制品和一种由该树脂产品组成的活性成分持续释放装置。
• POLYMER RESIN
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3789411A2

  公开（公告）日：2021-03-10

  Provided is a resin composition comprising a polymer that is capable of affording a heat storage material superior in humidity permeability and shape retention after phase transition and that is superior in molding processability, namely, a polymer including constitutional units (A) derived from ethylene, constitutional units (B) represented by a specified formula, and optionally including constitutional units (C) represented by a specified formula, wherein where the total number of the units (A), the units (B), and the units (C) is 100%, the number of the units (A) accounts for 70% to 99%, the total number of the units (B) and the units (C) accounts for 1% by weight to 30% by weight, and where the total number of the units (B) and the units (C) is 100%, the number of the units (B) accounts for 1% to 100% and the number of the units (C) accounts for 0% to 99%.

  本发明提供了一种树脂组合物，该树脂组合物包含一种聚合物，该聚合物能够提供一种在湿度渗透性和相变后形状保持性方面具有优异性能并且在成型加工性方面具有优异性能的蓄热材料，该聚合物包括由乙烯衍生的构型单元（A）、由指定式表示的构型单元（B）以及可选地包括由指定式表示的构型单元（C）、其中，当单元（A）、单元（B）和单元（C）的总数量为 100%时，单元（A）的数量占 70%至 99%，单元（B）和单元（C）的总数量占 1%至 30%（按重量计），而当单元（B）和单元（C）的总数量为 100%时，单元（B）的数量占 1%至 100%，单元（C）的数量占 0%至 99%。