2,3-dihydro-7-methyl-5-oxo-5H-thiazolo[3,2-a]pyridine-6-carbonitrile

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-dihydro-7-methyl-5-oxo-5H-thiazolo[3,2-a]pyridine-6-carbonitrile
• 英文别名: 7-Methyl-5-oxo-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-6-carbonitrile
• 化学式: C₉H₈N₂OS
• 分子量: 192.241
• InChiKey: AKYULTXTSUHABE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-thiazolidinylideneacetylacetone 、 氰乙酸乙酯 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以88%的产率得到2,3-dihydro-7-methyl-5-oxo-5H-thiazolo[3,2-a]pyridine-6-carbonitrile
  参考文献：
  名称：

  A FACILE METHOD FOR THE SYNTHESIS OF NOVEL PYRIDINONE DERIVATIVES VIA KETENEN,S-ACETALS

  摘要：

  A simple and easy method is provided for the synthesis of the novel pyridinone derivatives (3a-e), (8a-c) and (10a-c) by the reaction of ketene acetals (2a-e), (7a-c) and (9a-c) with ethyl cyanoacetate respectively. Compounds (3b-d) reacted with triethyl orthoformate to afford the pyridinone derivatives (4-6) respectively. Compound 7a reacted with ethyl acetoacetate or diethyl malonate to give thiazolopyridinone derivative 11 or 12 respectively.

  DOI：

  10.1081/scc-100106218

文献信息

• A FACILE METHOD FOR THE SYNTHESIS OF NOVEL PYRIDINONE DERIVATIVES VIA KETENE<i>N</i>,<i>S</i>-ACETALS
  作者：Eljazi I. Al-Afaleq

  DOI：10.1081/scc-100106218

  日期：2001.1

  A simple and easy method is provided for the synthesis of the novel pyridinone derivatives (3a-e), (8a-c) and (10a-c) by the reaction of ketene acetals (2a-e), (7a-c) and (9a-c) with ethyl cyanoacetate respectively. Compounds (3b-d) reacted with triethyl orthoformate to afford the pyridinone derivatives (4-6) respectively. Compound 7a reacted with ethyl acetoacetate or diethyl malonate to give thiazolopyridinone derivative 11 or 12 respectively.