4-phenyl-2-propyl-1-tosyl-4,5-dihydro-1H-imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenyl-2-propyl-1-tosyl-4,5-dihydro-1H-imidazole
• 英文别名: 1-(4-Methylphenyl)sulfonyl-4-phenyl-2-propyl-4,5-dihydroimidazole；1-(4-methylphenyl)sulfonyl-4-phenyl-2-propyl-4,5-dihydroimidazole
• 化学式: C₁₉H₂₂N₂O₂S
• 分子量: 342.462
• InChiKey: ALDOXQHWISWZEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁腈 、 2-苯基-1-甲苯磺酰啶 在 scandium tris(trifluoromethanesulfonate) 作用下， 反应 0.42h， 以84%的产率得到4-phenyl-2-propyl-1-tosyl-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  Sc(OTf)3-Catalyzed [3+2]-cycloaddition of aziridines with nitriles under solvent-free conditions

  摘要：

  [3+2]-Cycloaddition of aziridines with various nitriles in the absence of organic solvent catalyzed by Sc(OTf)(3) afforded the corresponding imidazolines in good to excellent yields under extremely mild reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.021

文献信息

• Sc(OTf)3-Catalyzed [3+2]-cycloaddition of aziridines with nitriles under solvent-free conditions
  作者：Jie Wu、Xiaoyu Sun、Hong-Guang Xia

  DOI：10.1016/j.tetlet.2006.01.021

  日期：2006.3

  [3+2]-Cycloaddition of aziridines with various nitriles in the absence of organic solvent catalyzed by Sc(OTf)(3) afforded the corresponding imidazolines in good to excellent yields under extremely mild reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.