taiwandimerol B

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: taiwandimerol B
• 化学式: C₂₀H₂₄O₇
• 分子量: 376.406
• InChiKey: AMPDGYCWLBGPQE-LADOFLMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  27.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  108.61
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  taiwandimerol B 、 三甲基硅烷化重氮甲烷 在 N,N-二异丙基乙胺 作用下， 以 甲醇 、 正己烷 、 乙腈 为溶剂， 反应 3.0h， 以5.2 mg的产率得到dimethyl taiwandimerol B
  参考文献：
  名称：

  Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

  摘要：

  Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallyl-catechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 mu M, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H(37)Rv, with MIC values of 30.3, 27.6, and 25.5 mu g/mL, respectively. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2013.03.008

文献信息

• Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities
  作者：Si Chen、Hung-Yi Huang、Ming-Jen Cheng、Chin-Chung Wu、Tsutomu Ishikawa、Chien-Fang Peng、Hsun-Shou Chang、Chyi-Jia Wang、Su-Ling Wong、Ih-Sheng Chen

  DOI：10.1016/j.phytochem.2013.03.008

  日期：2013.9

  Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallyl-catechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 mu M, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H(37)Rv, with MIC values of 30.3, 27.6, and 25.5 mu g/mL, respectively. (C) 2013 Elsevier Ltd. All rights reserved.