5-iodo-2-methyl-thiophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 5-iodo-2-methyl-thiophenol
• 英文别名: 5-Jod-thio-o-kresol；5-Jod-2-methyl-thiophenol；4-Jod-2-mercapto-toluol；5-Iodo-2-methylbenzenethiol；5-iodo-2-methylbenzenethiol
• 化学式: C₇H₇IS
• 分子量: 250.103
• InChiKey: ANMKHFADXKNYDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (5-iodo-2-methyl-phenyl)-trichloromethyl sulfide 在 苯胺 作用下， 生成 5-iodo-2-methyl-thiophenol
  参考文献：
  名称：

  Zincke; Rollhaeuser, Chemische Berichte, 1912, vol. 45, p. 1506

  摘要：

  DOI：

文献信息

• TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
  申请人：Mediconns (Shanghai) Biopharmaceutical Co., Ltd

  公开号：EP3733670A1

  公开（公告）日：2020-11-04

  The present invention discloses a tetrahydropyrrole compound, a preparation method therefor, a pharmaceutical composition containing the same, and a use thereof. The tetrahydropyrrole compound of the present invention is represented by general formula (I). The tetrahydropyrrole compound of the present invention has better inhibitory effects on the positive symptoms of schizophrenia, and the potency thereof is equivalent to or slightly stronger than that of the positive drug olanzapine. In addition, the compound of the present invention has dual inhibitory effects on D2 receptors and DAT receptors, and is effective for treating schizophrenia and improving negative symptoms and cognitive functions, while also reducing vertebral side effects and prolactin secretion.

  本发明公开了一种四氢吡咯化合物、其制备方法、含有该化合物的药物组合物及其用途。本发明的四氢吡咯化合物由通式（I）表示。本发明的四氢吡咯化合物对精神分裂症阳性症状有较好的抑制作用，其药效与阳性药物奥氮平相当或稍强于奥氮平。此外，本发明化合物对D2受体和DAT受体具有双重抑制作用，能有效治疗精神分裂症，改善阴性症状和认知功能，同时还能减少椎体副作用和催乳素分泌。
• Molecular and Polymeric Semiconductors and Related Devices
  申请人：Flexterra, Inc.

  公开号：US20170155053A1

  公开（公告）日：2017-06-01

  The present invention relates to new semiconducting compounds having at least one optionally substituted benzo[d][1,2,3]thiadiazole moiety. The compounds disclosed herein can exhibit high carrier mobility and/or efficient light absorption/emission characteristics, and can possess certain processing advantages such as solution-processability and/or good stability at ambient conditions.
• Zincke; Rollhaeuser, Chemische Berichte, 1912, vol. 45, p. 1506
  作者：Zincke、Rollhaeuser

  DOI：——

  日期：——