(2E,4E)-5-(2,5-dimethoxyphenyl)-1-(piperidin-1-yl)penta-2,4-diene-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,4E)-5-(2,5-dimethoxyphenyl)-1-(piperidin-1-yl)penta-2,4-diene-1-one
• 英文别名: (2E,4E)-5-(2,5-dimethoxyphenyl)-1-(piperidin-1-yl)-2,4-dien-1-one；LJ-2488；(2E,4E)-5-(2,5-dimethoxyphenyl)-1-piperidin-1-ylpenta-2,4-dien-1-one
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.386
• InChiKey: ANWRJKHIBPUTSS-KBXRYBNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-diethyl 4-oxo-4-(piperidin-1-yl)but-2-enylphosphoric acid 、 2,3-二甲氧基苯甲醛 在 potassium tert-butylate 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以78.6%的产率得到(2E,4E)-5-(2,5-dimethoxyphenyl)-1-(piperidin-1-yl)penta-2,4-diene-1-one
  参考文献：
  名称：

  NOVEL PIPERINE DERIVATIVES AND USES THEREOF

  摘要：

  本发明提供了新颖的胡椒碱衍生物。含有胡椒碱衍生物作为活性成分的药用或食品组合物对预防或治疗包括肥胖、糖尿病、血脂异常、脂肪肝和胰岛素抵抗综合征在内的代谢性疾病非常有效。本发明的胡椒碱衍生物作为药物组合物或功能性食品组合物具有治疗代谢综合征的疗效，包括肥胖、糖尿病、高血脂症、脂肪肝和胰岛素抵抗综合征，并且抑制前体细胞的分化并减少甘油三酯的积累。

  公开号：

  US20140371271A1

文献信息

• 신규한 펜타디에노일 피페리딘 유도체 및 그의 용도
  申请人：UIF (University Industry Foundation), Yonsei University 연세대학교 산학협력단(220050095099) BRN ▼110-82-10500

  公开号：KR101498218B1

  公开（公告）日：2015-03-12

  본 발명은 신규한 펜타디에노일 피페리딘 유도체, 이를 포함하는 대사질환의 예방 또는 치료용 약제학적 조성물 및 이를 이용한 대사질환의 개선 또는 완화용 기능성 식품 조성물에 관한 것이다. 본 발명의 펜타디에노일 피페리딘 유도체는 지방전구세포의 분화를 억제하며, 체중 및 내장지방을 감소시키고, 혈중 지질농도를 감소시키며, 혈중 간기능지표를 개선시키고, 혈당을 감소시킬 뿐 아니라 대사성염증반응을 억제함으로써 궁극적으로 비만, 당뇨, 이상지방혈증, 지방간 및 인슐린 저항성 증후군으로 구성된 군으로부터 선택되는 대사질환의 예방 또는 치료 활성을 나타내는 의약 또는 기능성 식품 조성물로서 유용하게 이용될 수 있다.

  本发明涉及一种新的戊二烯酰哌啶衍生物，以及包含该衍生物的用于预防或治疗代谢性疾病的药物组合物，以及用于改善或缓解代谢性疾病的功能性食品组合物。本发明的戊二烯酰哌啶衍生物抑制脂肪前体细胞的分化，减少体重和内脏脂肪，降低血液中的脂质含量，改善血液中的肝功能指标，降低血糖，并通过抑制代谢性炎症反应，最终表现为对由肥胖、糖尿病、血脂异常、脂肪肝和胰岛素抵抗综合征组成的代谢性疾病的预防或治疗活性。这种药物或功能性食品组合物可被有益地用于。
• Piperine derivatives and uses thereof
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US09321751B2

  公开（公告）日：2016-04-26

  The present invention provides novel piperine derivatives. The present pharmaceutical or food composition containing a piperine derivative as an active ingredient is very effective in preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome. Piperine derivatives of the present invention useful as pharmaceuticals compositions or functional food compositions has therapeutic efficacies for metabolic syndrome selected from the group consisting of obesity, diabetes, hyperlipidemia, fatty liver and insulin resistance syndrome, and also suppress the differentiation of progenitor cells and reduce the accumulation of triglycerides.

  本发明提供了新型的胡椒碱衍生物。本发明的药物或食品组合物含有胡椒碱衍生物作为活性成分，非常有效地预防或治疗代谢性疾病，包括肥胖症、糖尿病、血脂异常、脂肪肝和胰岛素抵抗综合征。本发明的胡椒碱衍生物可用作药物组合物或功能性食品组合物，具有治疗代谢综合征的疗效，所述代谢综合征选自肥胖症、糖尿病、高脂血症、脂肪肝和胰岛素抵抗综合征，并且抑制祖细胞的分化和减少三酰甘油的积累。
• NOVEL PIPERINE DERIVATIVE AND USE THEREFOR
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：EP2810941B1

  公开（公告）日：2017-03-15
• NOVEL PENTADIENOYL PIPERIDINE DERIVATIVE AND USE THEREOF
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：US20170320825A1

  公开（公告）日：2017-11-09

  The present invention relates to a novel pentadienoyl piperidine derivative, a pharmaceutical composition containing the same for prevention or treatment of metabolic diseases, and a functional food composition using the same for improvement or relief of metabolic diseases. The pentadienoyl piperidine derivative of the present invention inhibits the differentiation of preadipocytes, reduces body weight, visceral fat, blood lipid levels, and blood glucose levels, improves a blood liver function index, and suppresses metabolic inflammation responses. Thus, ultimately, the derivative can be usefully used as a medicine or a functional food composition, which exhibits the preventive or therapeutic activity for metabolic diseases selected from the group consisting of obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome.
• US9321751B2
  申请人：——

  公开号：US9321751B2

  公开（公告）日：2016-04-26