4-(2-Chloro-phenyl)-6-(2-hydroxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-Chloro-phenyl)-6-(2-hydroxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• 英文别名: 4-(2-chlorophenyl)-6-(2-hydroxyphenyl)-2-oxo-1H-pyridine-3-carbonitrile
• 化学式: C₁₈H₁₁ClN₂O₂
• 分子量: 322.751
• InChiKey: AOYVCCIKKHGBRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯苯甲醛 在 乙酸铵 、 sodium hydroxide 、 oxonium 作用下， 以 乙醇 为溶剂， 生成 4-(2-Chloro-phenyl)-6-(2-hydroxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
  参考文献：
  名称：

  Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers

  摘要：

  The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a . h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00361-9

文献信息

• Anti-inflammatory, analgesic and antipyretic 4,6-disubstituted 3-cyanopyridine-2-ones and 3-cyano-2-aminopyridines
  作者：F Manna、F Chimenti、A Bolasco、A Filippelli、A Palla、W Filippelli、E Lampa、R Mercantini

  DOI：10.1016/0223-5234(92)90141-m

  日期：1992.9

  3-Cyano-4-(RR'-aryl)-6(2-hydroxyphenyl)-2-(1H)pyridones 2a-o and 3-cyano-4-(R-R'-aryl)-6-(2-hydroxyphenyl)-2-aminopyridines were synthesized which showed anti-inflammatory and analgesic activity. Electron withdrawing substituents in 2' or 4' position on 4-aryl group of compounds 2 increased the anti-inflammatory activity, while their displacement in the 3' position produced an increase of analgesic activity and the appearance of an edematous reaction. All compounds showed low antipyretic and antimicrobial activity. The compounds 2b, 2d, 2i, 2m and 2o did not show any interesting activity in the beta-adrenolytic, antihypertensive and heart frequency tests.
• Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers
  作者：Fedele Manna、Franco Chimenti、Adriana Bolasco、Bruna Bizzarri、Maurizio Botta、Andrea Tafi、Amelia Filippelli、Settimio Rossi

  DOI：10.1016/s0960-894x(00)00361-9

  日期：2000.8

  The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a . h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem. (C) 2000 Elsevier Science Ltd. All rights reserved.