(4R,5R)-2,2-dihydro-3,4-dimethyl-5-phenyl-1,3-thiazolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R,5R)-2,2-dihydro-3,4-dimethyl-5-phenyl-1,3-thiazolidine
• 英文别名: (4R,5R)-3,4-dimethyl-5-phenyl-1,3-thiazolidine
• 化学式: C₁₁H₁₅NS
• 分子量: 193.313
• InChiKey: APHCCYOAIAOCEY-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1R,2R)-(-)-thiosulfonic deoxy-pseudo-ephedrine acid 在 盐酸 作用下， 以 氯仿 、 水 为溶剂， 反应 4.0h， 生成 (4R,5R)-2,2-dihydro-3,4-dimethyl-5-phenyl-1,3-thiazolidine
  参考文献：
  名称：

  A stereochemical study of optically active thiazolidines

  摘要：

  We report a stereochemical study of a series of free N-H and N-methylated 1,3-thiazolidines heating H or CH, at C-(2). These compounds were readily prepared from ephedrine and pseudoephedrines. The stereochemistry of the compounds under study was deduced using H-1 and C-13 NMR spectroscopy. Two isomers were found for compounds having a methyl group at C-(2) (i.e. C-(2)HCH3): interconversion of these isomers, presumably via a non-cyclic zwitterionic intermediate, was observed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00117-3

文献信息

• A stereochemical study of optically active thiazolidines
  作者：Alejandro Cruz、Aurora Vásquez-Badillo、Iris Ramos-Garcı́a、Rosalinda Contreras

  DOI：10.1016/s0957-4166(01)00117-3

  日期：2001.4

  We report a stereochemical study of a series of free N-H and N-methylated 1,3-thiazolidines heating H or CH, at C-(2). These compounds were readily prepared from ephedrine and pseudoephedrines. The stereochemistry of the compounds under study was deduced using H-1 and C-13 NMR spectroscopy. Two isomers were found for compounds having a methyl group at C-(2) (i.e. C-(2)HCH3): interconversion of these isomers, presumably via a non-cyclic zwitterionic intermediate, was observed. (C) 2001 Elsevier Science Ltd. All rights reserved.