N-benzyl-N-cyclohexyl-benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-cyclohexyl-benzenesulfonamide
• 英文别名: N-Benzyl-N-cyclohexyl-benzolsulfonamid；Benzolsulfonsaeure-cyclohexylbenzylamid；N-benzyl-N-cyclohexylbenzenesulfonamide
• 化学式: C₁₉H₂₃NO₂S
• 分子量: 329.463
• InChiKey: ASIBSXVGFFFWII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-cyclohexyl-benzenesulfonamide 在 Oxone 、 potassium bromide 作用下， 以 硝基甲烷 为溶剂， 反应 24.0h， 以96%的产率得到N-环己基苯磺酰胺
  参考文献：
  名称：

  Oxidative Debenzylation of N-Benzyl Amides and O-Benzyl Ethers Using Alkali Metal Bromide

  摘要：

  The oxidative debenzylation of N-benzyl amides and O-benzyl ethers was promoted with high efficiency by a bromo radical formed through the oxidation of bromide from alkali metal bromide under mild conditions. This reaction provided the corresponding amides from N-benzyl amides and carbonyl compounds from O-benzyl ethers in high yields.

  DOI：

  10.1021/ol501703y
• 作为产物：
  描述：

  苯甲腈 在 alkaline solution 、 镍 作用下， 110.0~130.0 ℃ 、2.03 MPa 条件下， 生成 N-benzyl-N-cyclohexyl-benzenesulfonamide
  参考文献：
  名称：

  Cloning and Characterization of the Promoter Region of the Human CD83 Gene

  摘要：

  Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC). To get insight into the regulation of hCD83 expression, we cloned a 3037 by fragment upstream of the translation initiation codon. Deletion mutants were constructed revealing highest promoter activity in the -261 fragment containing four SP1 binding sites and one NF-kappaB element. Electrophoretic mobility shift assays demonstrated the specific interaction of NF-kappaB factors with the NF-kappaB element as well as specific binding of SP1 and SP3 to the SP1 binding site. The hCD83 promoter was inducible by TNF-alpha. This inducibility was strictly dependent on the intact NF-kappaB element.

  DOI：

  10.1078/0171-2985-00128