三环[4.3.1.13,8]十一烷-3-胺 | 3048-63-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 三环[4.3.1.13,8]十一烷-3-胺
• 中文别名: 三环[4.3.1.1~3,8~]十一-3-基胺盐酸盐
• 英文名称: Homoadamantan-3-amin
• 英文别名: Tricyclo<4.3.1.1^3.8>undecan-3-amin；Tricyclo<4.3.1^3.8>undec-3-ylamin；3-Amino-homoadamantan；3-Aminohomoadamantan；3-Homoadamantylamin；Tricyclo[4.3.1.13,8]undecan-3-amine
• CAS: 3048-63-3
• 化学式: C₁₁H₁₉N
• mdl: MFCD00562665
• 分子量: 165.279
• InChiKey: YIMVAVCBOZTFKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921300090

反应信息

• 作为反应物：
  描述：

  三环[4.3.1.13,8]十一烷-3-胺 在 sodium nitrite 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 3-高金刚烷醇
  参考文献：
  名称：

  Langhals, Heinz; Mergelsberg, Ingrid; Ruechardt, Christoph, Chemische Berichte, 1982, vol. 115, # 4, p. 1509 - 1524

  摘要：

  DOI：
• 作为产物：
  描述：

  [Re(CH3NHNH2)(CO)(P(OEt)3)4](1+) 在 sodium hydroxide 作用下， 以 二乙二醇 为溶剂， 生成 三环[4.3.1.13,8]十一烷-3-胺
  参考文献：
  名称：

  抗病毒药。2.与1-金刚烷胺有关的化合物的构效关系。

  摘要：

  DOI：

  10.1021/jm00288a019

文献信息

• [EN] INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE<br/>[FR] INHIBITEURS DE L'INTÉGRINE ALPHA 2 BÊTA 1 ET PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2019178248A1

  公开（公告）日：2019-09-19

  Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.

  本文披露了抑制整合素α2β1的方法，以及使用这些方法的方法。
• ADAMANTANE ANALOGS
  申请人：DeGrado William F.

  公开号：US20120270917A1

  公开（公告）日：2012-10-25

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

  提供了能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒活性的化合物。还提供了治疗甲型流感受影响疾病状态或感染的方法，包括给予一个被鉴定为能够与M2蛋白相互作用的一个或多个化合物组成的组合物。
• Structure–Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers
  作者：Yanmei Hu、Raymond Kin Hau、Yuanxiang Wang、Peter Tuohy、Yongtao Zhang、Shuting Xu、Chunlong Ma、Jun Wang

  DOI：10.1021/acsmedchemlett.8b00336

  日期：2018.11.8

  Majority of current circulating influenza A viruses carry the S31N mutation in their M2 genes, rendering AM2-531N as a high profile antiviral drug target. With our continuous interest in developing AM2-531N channel blockers as novel antivirals targeting both oseltamivir-sensitive and -resistant influenza A viruses, we report herein the structure-property relationship studies of AM2-S31N inhibitors. The goal was to identify lead compounds with improved microsomal stability and membrane permeability. Two lead compounds, 10d and 10e, were found to have high mouse and human liver microsomal stability (T-1/2, > 145 min) and membrane permeability (> 200 nm/s). Both compounds also inhibit both currently circulating oseltamivir-sensitive and-resistant human influenza A viruses (H1N1 and H3N2) with EC50 values ranging from 0.4 to 2.8 mu M and a selectivity index of > 100. We also showed for the first time that AM2-S31N channel blockers such as 10e inhibited influenza virus replication at both low and high multiply of infection (10(2)-10(6) pfu/mL) and the inhibition was not cell-type dependent. Overall, these studies have identified two promising lead candidates for further development as antiviral drugs against drug-resistant influenza A viruses.
• One-pot amination of cage hydrocarbons
  作者：M. V. Leonova、M. Yu. Skomorokhov、I. K. Moiseev、Yu. N. Klimochkin

  DOI：10.1134/s1070428015120064

  日期：2015.12

  A one-pot procedure has been proposed for the synthesis of amines directly from cage hydrocarbons. A number of cage amines have been synthesized by treatment of adamantane, its homologs, and structurally related cage hydrocarbons with nitric acid in acetic acid and subsequent addition of urea and heating.
• Certain regroupings of adamantane
  作者：F. N. Stepanov、S. S. Guts

  DOI：10.1007/bf00853388

  日期：1970.2