rel(3R,4R,8aS)-8a-methoxy-2-spirocyclohexyl-3,4-oxiranyl-6H-chroman-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧环庚烷
• 英文名称: rel(3R,4R,8aS)-8a-methoxy-2-spirocyclohexyl-3,4-oxiranyl-6H-chroman-6-one
• 英文别名: (1aR,3aS,7bR)-3a-methoxyspiro[1a,7b-dihydrooxireno[2,3-c]chromene-2,1'-cyclohexane]-6-one
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: ASMWWFQIURADRC-NFAWXSAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  48.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-碘苯酚 在 Lindlar's catalyst 咪唑 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 1,1,3-三甲基-3-苯基二氢化茚-4,5-二甲酸 、 氢气 、 二异丙胺 、 间氯过氧苯甲酸 、 cesium fluoride 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 49.0h， 生成 rel(3R,4R,8aS)-8a-methoxy-2-spirocyclohexyl-3,4-oxiranyl-6H-chroman-6-one
  参考文献：
  名称：

  The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

  摘要：

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00008-2

文献信息

• The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation
  作者：Andrew Pelter、Amjad Hussain、Gareth Smith、Robert S Ward

  DOI：10.1016/s0040-4020(97)00008-2

  日期：1997.3

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.