2,2-dimethylpropionic acid 2-[2-(2,6-bis-allyloxy-4-{2-[2-(3,5-bis-allyloxy-4-{2-[2-(2,2-dimethylpropionyloxy)ethoxy]ethoxy}benzoylamino)ethyldisulfanyl]ethylcarbamoyl}phenoxy)ethoxy]ethyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethylpropionic acid 2-[2-(2,6-bis-allyloxy-4-{2-[2-(3,5-bis-allyloxy-4-{2-[2-(2,2-dimethylpropionyloxy)ethoxy]ethoxy}benzoylamino)ethyldisulfanyl]ethylcarbamoyl}phenoxy)ethoxy]ethyl ester
• 英文别名: 2-[2-[4-[2-[2-[[4-[2-[2-(2,2-Dimethylpropanoyloxy)ethoxy]ethoxy]-3,5-bis(prop-2-enoxy)benzoyl]amino]ethyldisulfanyl]ethylcarbamoyl]-2,6-bis(prop-2-enoxy)phenoxy]ethoxy]ethyl 2,2-dimethylpropanoate
• 化学式: C₄₈H₆₈N₂O₁₄S₂
• 分子量: 961.205
• InChiKey: AWAAKOUKZVQDIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  66
• 可旋转键数：
  39
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  235
• 氢给体数：
  2
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  三甲基乙酸酐 、 在 molybdenium(VI) dioxodichloride 作用下， 以 二氯甲烷 为溶剂， 反应 48.17h， 以84%的产率得到2,2-dimethylpropionic acid 2-[2-(2,6-bis-allyloxy-4-{2-[2-(3,5-bis-allyloxy-4-{2-[2-(2,2-dimethylpropionyloxy)ethoxy]ethoxy}benzoylamino)ethyldisulfanyl]ethylcarbamoyl}phenoxy)ethoxy]ethyl ester
  参考文献：
  名称：

  Nucleophilic Acyl Substitutions of Anhydrides with Protic Nucleophiles Catalyzed by Amphoteric, Oxomolybdenum Species

  摘要：

  [GRAPHICS]Among six different group VIb oxometallic species examined, dioxomolybdenum dichloride and oxomolybdenum tetrachloride were the most efficient catalysts to facilitate nucleophilic acyl substitution (NAS) of anhydrides with a myriad array of alcohols, amines, and thiols in high yields and high chemoselectivity. In contrast to the well-recognized redox chemical behaviors associated with oxomolybdenum(VI) species, the catalytic NAS was unprecedented and tolerates virtually all kinds of functional groups. By using benzoic anhydride as a mediator for in situ generation of an incipient mixed anhydride -MoO2Cl2 adduct with a given functional alkanoic acid, one can achieve oleate, dipeptide, diphenylmethyl, N-Fmoc-alpha-amino, pyruvic, and tert-butylthio ester, N-tert-butylamide, and trityl methacrylate syntheses with appropriate protic nucleophiles. The amphoteric character of the Mo=O unit in oxomolybdenum chlorides was found to be responsible for the catalytic NAS profile as supported by a control NAS reaction of using an authentic adduct-MoOCl2(O-2-CBut)(2) between pivalic anhydride and MoO2Cl2 as the catalyst.

  DOI：

  10.1021/jo048363v

文献信息

• Nucleophilic Acyl Substitutions of Anhydrides with Protic Nucleophiles Catalyzed by Amphoteric, Oxomolybdenum Species
  作者：Chien-Tien Chen、Jen-Huang Kuo、Vijay D. Pawar、Yogesh S. Munot、Shieu-Shien Weng、Cheng-Hsiu Ku、Cheng-Yuan Liu

  DOI：10.1021/jo048363v

  日期：2005.2.1

  [GRAPHICS]Among six different group VIb oxometallic species examined, dioxomolybdenum dichloride and oxomolybdenum tetrachloride were the most efficient catalysts to facilitate nucleophilic acyl substitution (NAS) of anhydrides with a myriad array of alcohols, amines, and thiols in high yields and high chemoselectivity. In contrast to the well-recognized redox chemical behaviors associated with oxomolybdenum(VI) species, the catalytic NAS was unprecedented and tolerates virtually all kinds of functional groups. By using benzoic anhydride as a mediator for in situ generation of an incipient mixed anhydride -MoO2Cl2 adduct with a given functional alkanoic acid, one can achieve oleate, dipeptide, diphenylmethyl, N-Fmoc-alpha-amino, pyruvic, and tert-butylthio ester, N-tert-butylamide, and trityl methacrylate syntheses with appropriate protic nucleophiles. The amphoteric character of the Mo=O unit in oxomolybdenum chlorides was found to be responsible for the catalytic NAS profile as supported by a control NAS reaction of using an authentic adduct-MoOCl2(O-2-CBut)(2) between pivalic anhydride and MoO2Cl2 as the catalyst.