1-bromo-2-heptanol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-bromo-2-heptanol
• 英文别名: 1-Bromoheptanol；1-bromoheptan-1-ol
• 化学式: C₇H₁₅BrO
• 分子量: 195.1
• InChiKey: AYKPZMBMMDXASY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-bromo-2-heptanol 在 sodium hydroxide 、 2,3-二甲基苯胺 作用下， 以 苯 为溶剂， 反应 7.5h， 生成 Acetic acid 1-p-tolyloxymethyl-hexyl ester
  参考文献：
  名称：

  Alekperov, R. K.; Gasanov, V. S., Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1944 - 1948

  摘要：

  DOI：

文献信息

• Bisaryl derivatives having FSH modulatory activity
  申请人：——

  公开号：US20040152703A1

  公开（公告）日：2004-08-05

  The invention relates to bisaryl derivatives of the formula I, 1 wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); Ar is substituted phenyl and A is a group of formula II, III, IV or V: 2 An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimethoxyphenyl)benzyl)-4-N-methyl-6-methyl-2,5-dioxo-1,4-piperazine: 3 The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.

  该发明涉及公式I的双芳基衍生物，其中(R,R)从(H,H)，O，(H,CH3)，(H,OH)和(H,CN)中选择；Ar是取代苯基，A是公式II，III，IV或V的基团之一：一个例子是(3S,6S)-1-N-(7-苯基庚基)-3-(4-(3,4,5-三甲氧基苯基)苯基)-4-N-甲基-6-甲基-2,5-二氧杂环己烷：该发明的化合物具有FSH受体调节活性，可用于控制生育、避孕或治疗激素依赖性疾病。
• 2,2-Disubstituted glycerol and glycerol-like compounds, compositions and methods of use
  申请人：SCHERING CORPORATION

  公开号：EP0327962A1

  公开（公告）日：1989-08-16

  Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula wherein R1, R2, R3, and R4 are as defined in the specification.

  本发明揭示了用作抗过敏和抗炎化合物的新型2,2-二取代甘油化合物。这些化合物是血小板活化因子（“PAF”）的拮抗剂。本发明还揭示了合成和使用本发明化合物的方法以及其制药组合物。该化合物的化学式为其中R1、R2、R3和R4如规范中定义。
• Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
  申请人：Galderma Research & Development, S.N.C.

  公开号：US20040092594A1

  公开（公告）日：2004-05-13

  Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula. (I): 1 in which Ar 1 is a radical having one of the structural formulae (a)-(c): 2 Ar 2 is a radical having one of the following formulae (d)-(h): 3 and X is a radical having one of the following formulae (i)-(l): 4 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  具有药用/化妆品活性的双环芳香化合物具有结构式（I）：1其中Ar1是具有结构式（a）-（c）之一的基团：2Ar2是具有以下式（d）-（h）之一的基团：3而X是具有以下式（i）-（l）之一的基团：4并且对于治疗各种疾病状态（无论是人类还是兽医），例如皮肤病，风湿病，呼吸系统疾病，心血管疾病和眼科疾病以及哺乳动物皮肤和毛发状况/疾病的治疗非常有用。
• Method for producing of phthalocyanine compound
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0882768A2

  公开（公告）日：1998-12-09

  A method for producing a novel phthalocyanine compound which excels in yield and purity, allows no introduction of a chlorine atom into the phthalocyanine skeleton, and possesses relatively bulky substituents is provided. This method is characterized by causing an orthophthalonitrile compound having a substituent exhibiting smaller σp values than σm values in the Hammett's rule to react with a metal oxide in the presence of a compound forming in the aqueous solution thereof at 25°C an acid or conjugate acid having a dissociation index pKa (the logarithmic value of the reciprocal of the dissociation constant of the acid or conjugate acid) of not more than 7.0.

  本发明提供了一种生产新型酞菁化合物的方法，该方法产量高、纯度高，不允许在酞菁骨架中引入氯原子，并具有相对笨重的取代基。 该方法的特点是，在 25°C 时，在其水溶液中形成的酸或共轭酸的化合物存在下，使具有取代基的 σp 值小于哈密特规则中的σm 值的邻苯二甲腈化合物与金属氧化物反应，该酸或共轭酸的离解指数 pKa（酸或共轭酸的离解常数倒数的对数值）不大于 7.0。
• PHTHALOCYANINE COMPOUNDS, PROCESS FOR PREPARING THE SAME, AND OPTICAL RECORDING MEDIUM MADE USING THE SAME
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0889097A1

  公开（公告）日：1999-01-07

  A phthalocyanine compound of a structural formula of phthalocyanine represented by the general formula (1): wherein 1 to 8 of a total 16 positions are substituted with a phenoxy group, the phenoxy group at either of the ortho positions is substituted with an aryl group which may be substituted, all the atoms in the aryl group and the substituents at the residual ortho positions excluding the hydrogen atoms assume a total atomic radius of not less than 6.0 Å, and a central atom group M contains a metal atom of not less than trivalence, a bromine-substituent of the compound, a phthalocyanine composition comprising the phthalocyanine compound and the bromine atom-containing phthalocyanine compound, and an optical recording medium containing it in a recording layer.

  一种酞菁化合物，其酞菁的结构式由通式(1)代表： 其中在总共 16 个位置中的 1 至 8 个位置被苯氧基取代，在任一正交位置上的苯氧基被可被取代的芳基取代，芳基中的所有原子和残余正交位置上的取代基（不包括氢原子）的总原子半径不小于 6.0 Å，中心原子基团 M 含有不小于三价的金属原子、该化合物的溴取代基、由该酞菁化合物和含溴原子的酞菁化合物组成的酞菁组合物，以及在记录层中含有它的光学记录介质。