(S)-4-isopropyl-2-(pyrazin-2-yl)-4,5-dihydrooxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-4-isopropyl-2-(pyrazin-2-yl)-4,5-dihydrooxazole
• 英文别名: (S)-4-Isopropyl-2-(pyrazin-2-yl)-4,5-dihydrooxazole；(4S)-4-propan-2-yl-2-pyrazin-2-yl-4,5-dihydro-1,3-oxazole
• 化学式: C₁₀H₁₃N₃O
• 分子量: 191.233
• InChiKey: AYMSXIFDZOUXRX-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氰基吡嗪 、 L-缬氨醇 以 neat (no solvent) 为溶剂， 反应 1.0h， 以83%的产率得到(S)-4-isopropyl-2-(pyrazin-2-yl)-4,5-dihydrooxazole
  参考文献：
  名称：

  Efficacious and rapid metal- and solvent-free synthesis of enantiopure oxazolines

  摘要：

  A rapid and efficient synthesis of oxazolines was performed starting from various nitriles using microwave irradiation combined to metal- and solvent-free conditions to afford high to quantitative yields of the targeted heterocycles. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.08.010

文献信息

• Efficacious and rapid metal- and solvent-free synthesis of enantiopure oxazolines
  作者：Rym Hassani、Alexandre Requet、Sylvain Marque、Anne Gaucher、Damien Prim、Yakdhane Kacem、Béchir Ben Hassine

  DOI：10.1016/j.tetasy.2014.08.010

  日期：2014.10

  A rapid and efficient synthesis of oxazolines was performed starting from various nitriles using microwave irradiation combined to metal- and solvent-free conditions to afford high to quantitative yields of the targeted heterocycles. (C) 2014 Elsevier Ltd. All rights reserved.