3-aminobenzaldehyde oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-aminobenzaldehyde oxime
• 英文别名: m-aminobenzaldehyde oxime；Benzaldehyde, 3-amino-, oxime；(NE)-N-[(3-aminophenyl)methylidene]hydroxylamine
• 化学式: C₇H₈N₂O
• 分子量: 136.153
• InChiKey: BAIFPWUZMRFFFX-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基苯甲醛 在 盐酸羟胺 作用下， 以 乙醇 、 水 为溶剂， 反应 0.17h， 以80%的产率得到3-aminobenzaldehyde oxime
  参考文献：
  名称：

  The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon

  摘要：

  Important defense agents against chemical warfare weapons, which are reactivators of human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus compounds (OP), need a reasonable permeation of the hematoencephalic barrier (HB). In this work, neutral oximes, which permeate HB better than the cationic oximes currently used as defense agents, were tested as reactivators of huAChE inhibited with paraoxon using the modified Ellman test with pralidoxime (2-PAM) as positive standard. The most active neutral oxime was (thiophen-2-yl) aldoxime, which reactivated 93% of the inhibited huAChE and was 12% more effective than 2-PAM. The results showed that simple neutral oximes have potential to function as antidotes for intoxication with neurotoxic OPs, suggesting further research on the development of neutral defense agents.

  DOI：

  10.1590/s0103-50532012000700004

文献信息

• N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF
  申请人：Shi Jiangong

  公开号：US20130045942A1

  公开（公告）日：2013-02-21

  The present invention provides N 6 -substituted adenosine derivatives and N 6 -substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了N6-取代腺苷衍生物和N6-取代腺嘌呤衍生物，其制备方法，包括上述化合物的药物组合物，以及这些化合物在制造治疗失眠、惊厥、癫痫和帕金森病的药物和保健产品以及预防和治疗痴呆症中的用途。
• Metal-Free, Rapid, and Highly Chemoselective Reduction of Aromatic Nitro Compounds at Room Temperature
  作者：Mingyeong Jang、Taeho Lim、Byoung Yong Park、Min Su Han

  DOI：10.1021/acs.joc.1c01431

  日期：2022.1.21

  this study, we developed a metal-free and highly chemoselective method for the reduction of aromatic nitro compounds. This reduction was performed using tetrahydroxydiboron [B2(OH)4] as the reductant and 4,4′-bipyridine as the organocatalyst and could be completed within 5 min at room temperature. Under optimal conditions, nitroarenes with sensitive functional groups, such as vinyl, ethynyl, carbonyl

  在这项研究中，我们开发了一种无金属且高度化学选择性的芳族硝基化合物还原方法。这种还原是使用四羟基二硼[B 2 (OH) 4 ] 作为还原剂和4,4'-联吡啶作为有机催化剂进行的，并且可以在室温下在5分钟内完成。在最佳条件下，具有敏感官能团（如乙烯基、乙炔基、羰基和卤素）的硝基芳烃以优异的选择性转化为相应的苯胺，同时避免了敏感官能团的不良还原。
• HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL
  申请人：Ihara Hideki

  公开号：US20110294840A1

  公开（公告）日：2011-12-01

  There is provided a hydrazide compound having a controlling effect on pests represented by the formula (1): wherein, G is a 5-membered heterocyclic group, M is an oxygen atom or a sulfur atom, Q 1 , Q 2 , Q 3 and Q 4 is independently a nitrogen atom, etc., m is an integer of 0 to 5, R 2 is an optionally halogenated C1-C6 alkyl group, etc., R 5 and R 6 are independently an optionally substituted C1-C12 chain hydrocarbon group, etc., and R 4 is an optionally substituted C1-C12 chain hydrocarbon group, etc.

  提供一种对害虫具有控制作用的肼类化合物，其化学式表示为（1）：其中，G是一个五元杂环基团，M是一个氧原子或硫原子，Q1、Q2、Q3和Q4分别是氮原子等，m是0到5的整数，R2是一个可选卤代的C1-C6烷基基团等，R5和R6分别是可选取代的C1-C12链烃基团等，R4是一个可选取代的C1-C12链烃基团等。
• N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2511283A1

  公开（公告）日：2012-10-17

  The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了 N6-取代腺苷衍生物和 N6-取代腺嘌呤衍生物、其制造方法、包含上述化合物的药物组合物，以及这些化合物在制造治疗失眠、抽搐、癫痫和帕金森病以及预防和治疗痴呆症的药物和保健产品中的用途。
• N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof
  申请人：Shi Jiangong

  公开号：US10174033B2

  公开（公告）日：2019-01-08

  The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了 N6-取代腺苷衍生物和 N6-取代腺嘌呤衍生物、其制造方法、包含上述化合物的药物组合物，以及这些化合物在制造治疗失眠、抽搐、癫痫和帕金森病以及预防和治疗痴呆症的药物和保健产品中的用途。