(4-(trifluoromethyl)phenyl)decane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(trifluoromethyl)phenyl)decane
• 英文别名: 1-[4-(Trifluoromethyl)phenyl]decane；1-decyl-4-(trifluoromethyl)benzene
• 化学式: C₁₇H₂₅F₃
• 分子量: 286.381
• InChiKey: BAMOGYMWLMMOKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-辛基氯化镁, 1M IN METHF 、 对三氟甲基苯乙基溴 在 C₁₈H₂₂ClN₃Ni 作用下， 以63%的产率得到(4-(trifluoromethyl)phenyl)decane
  参考文献：
  名称：

  From Dimethylamine to Pyrrolidine: The Development of an Improved Nickel Pincer Complex for Cross-Coupling of Nonactivated Secondary Alkyl Halides

  摘要：

  Replacement of a dimethyl amino group of the amidobis(amine) nickel(II) pincer complex (1), [((N2N)-N-Me)-Ni-Cl], by a pyrrolidino group resulted in a new nickel(II) pincer complex (2), [((PNNN)-N-yr-N-Me)Ni-Cl]. Complex 2 is an efficient catalyst for Kumada and Suzuki-Miyaura cross-coupling of nonactivated secondary alkyl halides, while complex 1 is largely inactive. The significant activity difference is tentatively attributed to a minimal structural difference, which leads to a more hemilabile ligand.

  DOI：

  10.1021/acscatal.5b02324

文献信息

• Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling
  作者：Samantha A. Green、Jeishla L. M. Matos、Akiko Yagi、Ryan A. Shenvi

  DOI：10.1021/jacs.6b08507

  日期：2016.10.5

  A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.

  钴和镍催化循环的组合实现了高度分支选择性（马尔科夫尼科夫）烯烃加氢芳基化。自由基环化和断环实验与碳中心自由基的氢原子转移 (HAT) 生成一致，从而导致镍循环的参与。
• Glycolipids And Analogues Thereof As Antigens For NKT Cells
  申请人：Tsuji Moriya

  公开号：US20070238871A1

  公开（公告）日：2007-10-11

  This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
• GLYCOLIPIDS AND ANALOGUES THEREOF AS ANTIGENS FOR NKT CELLS
  申请人：TSUJI Moriya

  公开号：US20120258142A1

  公开（公告）日：2012-10-11

  This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
• US7923013B2
  申请人：——

  公开号：US7923013B2

  公开（公告）日：2011-04-12
• US8163290B2
  申请人：——

  公开号：US8163290B2

  公开（公告）日：2012-04-24