bis-4-benzyloxybenzyl ether | 345658-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-4-benzyloxybenzyl ether
• 英文别名: Dibenzyloxide, 4,4'-bis(benzyloxy)-；1-phenylmethoxy-4-[(4-phenylmethoxyphenyl)methoxymethyl]benzene
• CAS: 345658-16-4
• 化学式: C₂₈H₂₆O₃
• 分子量: 410.513
• InChiKey: BAQRJVCTTBLZOH-UHFFFAOYSA-N

物化性质

• 沸点：
  558.5±45.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-(benzyloxy)benzyloxy)trimethylsilane 在 硫酸 、 silica gel 作用下， 以 正己烷 为溶剂， 反应 0.25h， 以85%的产率得到bis-4-benzyloxybenzyl ether
  参考文献：
  名称：

  Silica Sulfuric Acid: An Efficient Catalyst for the Direct Conversion of Primary and Secondary Trimethylsilyl Ethers to their Corresponding Ethers under Mild and Heterogeneous Conditions

  摘要：

  在温和且异相的条件下，初级和次级三甲基硅基醚在硅酸硫酸的存在下转化为相应的醚，产率良好至优秀。

  DOI：

  10.1055/s-2003-41469

文献信息

• NITROIMIDAZOOXAZINE AND NITROIMIDAZOOXAZOLE ANALOGUES AND THEIR USES
  申请人：Thompson Andrew Mark

  公开号：US20110028466A1

  公开（公告）日：2011-02-03

  The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for Mycobacterium tuberculosis , for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency against Trypanosoma cruzi or Leishmania donovani , and for the treatment of other microbial infections.

  当前的发明涉及硝基咪唑噁啉和硝基咪唑噁唑类似物，它们的制备方法，以及将这些化合物用作治疗结核分枝杆菌、用作抗结核药物、用作对克氏锥虫或唐氏利什曼原虫具有意外高效的抗原虫药剂，以及用于治疗其他微生物感染的用途。
• [EN] NITROIMIDAZOOXAZINE AND NITROIMIDAZOOXAZOLE ANALOGUES AND THEIR USES<br/>[FR] ANALOGUES DE NITRO-IMIDAZO-OXAZINE ET DE NITRO-IMIDAZO-OXAZOLE ET LEURS UTILISATIONS
  申请人：GLOBAL ALLIANCE FOR TB DRUG DEV

  公开号：WO2011014776A1

  公开（公告）日：2011-02-03

  The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for Mycobacterium tuberculosis, for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency against Trypanosoma cruzi or Leishmania donovani, and for the treatment of other microbial infections.

  本发明涉及硝基咪唑氧杂环丙烷和硝基咪唑氧杂环咪唑类似物，它们的制备方法以及将这些化合物用作治疗结核分枝杆菌的药物，用作抗结核药物，用作抗原虫药物，对Trypanosoma cruzi或Leishmania donovani具有意外高效的药物，并用于治疗其他微生物感染。
• The use of Nafion-H® as an efficient catalyst for the direct conversion of primary and secondary trimethylsilyl ethers to their corresponding ethers under mild and heterogeneous conditions
  作者：Mohammad Ali Zolfigol、Iraj Mohammadpoor-Baltork、Davood Habibi、BiBi Fatemeh Mirjalili、Abdolhamid Bamoniri

  DOI：10.1016/j.tetlet.2003.09.036

  日期：2003.10

  Primary and secondary trimethylsilyl ethers were converted to their corresponding ethers in the presence Nafion-H(R) with good to excellent yields under mild and heterogeneous conditions. (C) 2003 Elsevier Ltd. All rights reserved.
• High‐Efficiency Conversion of Trimethylsilyl Ethers to Their Corresponding Ethers using Carbon‐Based Solid Acid as a New Catalyst in Heterogeneous Mixtures
  作者：Arash Shokrollahi、Abbas Zali、Hamid Reza Pouretedal

  DOI：10.1080/00397910701767080

  日期：2008.1.1

  Carbon-based solid acid was used as a new catalyst for conversion of trimethylsilyl ethers to their corresponding ethers in heterogeneous mixtures. The experiments were done moderately at room temperature, and high yields in suitable times were obtained under these conditions.
• An Efficient Process for the Synthesis of γ-Arylbutanals via Copper-Mediated Grignard Coupling
  作者：William T. Monte、Aline C. Lindbeck

  DOI：10.1021/op010202v

  日期：2001.5.1

  Copper-mediated Grignard cross-coupling of beta -bromoethylene acetals with substituted benzyl halides can be combined with hydrolytic deprotection for an efficient and practical scale-up process to form gamma -arylbutanals.