3-phenylbut-3-en-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenylbut-3-en-2-ol
• 英文别名: (2R)-3-phenylbut-3-en-2-ol
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: BCHFPTSXLVGIFV-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以81.5%的产率得到
  参考文献：
  名称：

  Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ

  摘要：

  Chiral alpha-aryl substituted allylic alcohols are important versatile synthetic intermediates. We report here an effective nonenzymatic kinetic resolution of racemic alpha-aryl substituted allylic alcohols by introducing different aryl groups with acyl transfer catalyst Np-PIQ and propionic anhydride, providing moderate to good selectivity factors (S=12-37). (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.01.018

文献信息

• Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ
  作者：Shan-Shan Jiang、Bo-Qi Gu、Ming-Yu Zhu、Xingxin Yu、Wei-Ping Deng

  DOI：10.1016/j.tet.2015.01.018

  日期：2015.2

  Chiral alpha-aryl substituted allylic alcohols are important versatile synthetic intermediates. We report here an effective nonenzymatic kinetic resolution of racemic alpha-aryl substituted allylic alcohols by introducing different aryl groups with acyl transfer catalyst Np-PIQ and propionic anhydride, providing moderate to good selectivity factors (S=12-37). (C) 2015 Elsevier Ltd. All rights reserved.