6-Hydroxy-pyridine-2-carboxylic acid propylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-Hydroxy-pyridine-2-carboxylic acid propylamide
• 英文别名: 6-oxo-N-propyl-1H-pyridine-2-carboxamide
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: BDCJVISVHAHCRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-羟基吡啶-2-羧酸 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 6-Hydroxy-pyridine-2-carboxylic acid propylamide
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates

  摘要：

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.

  DOI：

  10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e

文献信息

• Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates
  作者：Bruce L. Finkelstein、Melissa A. Martz、Christopher J. Strock

  DOI：10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e

  日期：1997.8

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.