dibenzyl (3Z,4E)-3-(1-(2-benzoylphenyl)ethylidene)-4-ethylidenecyclopentane-1,1-dicarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzyl (3Z,4E)-3-(1-(2-benzoylphenyl)ethylidene)-4-ethylidenecyclopentane-1,1-dicarboxylate
• 英文别名: dibenzyl (3Z,4E)-3-[1-(2-benzoylphenyl)ethylidene]-4-ethylidenecyclopentane-1,1-dicarboxylate
• 化学式: C₃₈H₃₄O₅
• 分子量: 570.685
• InChiKey: BEJZWMCHUZSZAG-IXVDQSCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二苯甲酮 、 dibenzyl 2,2-di(but-2-ynyl)malonate 在 [Rh(2,2'-bis(diphenylphosphino)-1,1'-biphenyl)]BF₄ 作用下， 以 二氯甲烷 为溶剂， 反应 0.58h， 生成 dibenzyl (3Z,4E)-3-(1-(2-benzoylphenyl)ethylidene)-4-ethylidenecyclopentane-1,1-dicarboxylate 、 dibenzyl (3E,4E)-3-(1-(2-benzoylphenyl)ethylidene)-4-ethylidenecyclopentane-1,1-dicarboxylate
  参考文献：
  名称：

  Rh-Catalyzed Cyclization of Diynes and Enynes Initiated by Carbonyl-Directed Activation of Aromatic and Vinylic C−H Bonds

  摘要：

  [GRAPHICS]The Rh-catalyzed hydroarylative and hydrovinylative cyclization of diynes with aryl ketones or enones gave monocyclic 1,3-dienes. Enynes also underwent the same reaction and chiral products were obtained with high ee using a chiral Rh catalyst. Carbonyl-directed activation of aromatic and vinylic C-H bonds is likely the initial step in the present transformation.

  DOI：

  10.1021/ol0711669

文献信息

• Rh-Catalyzed Cyclization of Diynes and Enynes Initiated by Carbonyl-Directed Activation of Aromatic and Vinylic C−H Bonds
  作者：Kyoji Tsuchikama、Yusuke Kuwata、Yu-ki Tahara、Yusuke Yoshinami、Takanori Shibata

  DOI：10.1021/ol0711669

  日期：2007.8.1

  [GRAPHICS]The Rh-catalyzed hydroarylative and hydrovinylative cyclization of diynes with aryl ketones or enones gave monocyclic 1,3-dienes. Enynes also underwent the same reaction and chiral products were obtained with high ee using a chiral Rh catalyst. Carbonyl-directed activation of aromatic and vinylic C-H bonds is likely the initial step in the present transformation.