2-ethynyl-5-isopropoxy-4-methoxybenzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethynyl-5-isopropoxy-4-methoxybenzaldehyde
• 英文别名: 2-Ethynyl-4-methoxy-5-propan-2-yloxybenzaldehyde
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.252
• InChiKey: BENTZEMREBQOQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-二甲氧基-3,4-二氢异喹啉 、 碘乙酸 、 5-碘-2-甲氧基苯酚 、 2-ethynyl-5-isopropoxy-4-methoxybenzaldehyde 以9%的产率得到3-O-isopropyllamellarin U
  参考文献：
  名称：

  Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis

  摘要：

  The application of a number of Lewis acids as a cleavage/deprotection method in the solid-phase synthesis of organic molecules can render several analogues, which, after purification, can be submitted for biological evaluation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.119

文献信息

• Solid-Phase Total Synthesis of the Pentacyclic System Lamellarins U and L
  作者：Pablo Cironi、Ignacio Manzanares、Fernando Albericio、Mercedes Álvarez

  DOI：10.1021/ol0351192

  日期：2003.8.1

  A total solid-phase synthesis of lamellarins U and L has been achieved. The conversion of an aldehyde group into a formate by a Baeyer-Villiger reaction and a intramolecular [3 + 2] cycloaddition of a 3,4-dihydroisoquinolinium salt over a triple bond comprise the key steps of the process. Each transformation has been controlled with the proper spectroscopic and analytical methods.
• EP1613635A2
  申请人：——

  公开号：EP1613635A2

  公开（公告）日：2006-01-11
• Solid phase synthesis of antitumoral compounds
  申请人：Alvarez Mercedes

  公开号：US20060287529A1

  公开（公告）日：2006-12-21

  Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R 1 to R 15 are as defined, and X is halogen, provided that one of R 2 , R 3 or R 4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R 1 ′ to R 5 ′, R 11 ′ and R 13 ′ are as defined, X 1 and X 2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R 2 ′, R 3 ′ or R 4 ′ is immobilised to a resin.
• [EN] SOLID PHASE SYNTHESIS OF ANTITUMORAL COMPOUNDS<br/>[FR] SYNTHESE EN PHASE SOLIDE DE COMPOSES ANTITUMORAUX
  申请人：PHARMA MAR SAU

  公开号：WO2004073598A2

  公开（公告）日：2004-09-02

  Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R1 to R15 are as defined, and X is halogen, provided that one of R2, R3 or R4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R1' to R5', R11' and R13' are as defined, X1 and X2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R2', R3' or R4' is immobilised to a resin.
• Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis
  作者：Pablo Cironi、Carmen Cuevas、Fernando Albericio、Mercedes Álvarez

  DOI：10.1016/j.tet.2004.05.119

  日期：2004.9

  The application of a number of Lewis acids as a cleavage/deprotection method in the solid-phase synthesis of organic molecules can render several analogues, which, after purification, can be submitted for biological evaluation. (C) 2004 Elsevier Ltd. All rights reserved.