10-benzyl-8-methyl-1,10-diazabicyclo[7.4.0]tridecane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 10-benzyl-8-methyl-1,10-diazabicyclo[7.4.0]tridecane
• 英文别名: 1-benzyl-12-methyl-3,4,6,7,8,9,10,11,12,12a-decahydro-2H-pyrimido[1,2-a]azonine
• 化学式: C₁₉H₃₀N₂
• 分子量: 286.461
• InChiKey: BEZORAZYWWXCIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(oct-7-enyl)propane-1,3-diamine 在 dirhodium tetraacetate 、 三苯基膦 sodium tetrahydroborate 、 氢气 作用下， 以 甲醇 、 苯 为溶剂， 80.0 ℃ 、2.76 MPa 条件下， 反应 25.0h， 生成 10-benzyl-8-methyl-1,10-diazabicyclo[7.4.0]tridecane
  参考文献：
  名称：

  A Hydroformylation Route to Diazabicycloalkanes and Oxazabicycloalkanes Containing Medium and Large Rings

  摘要：

  含有中环和大环的重氮双环烷烃和恶唑双环烷烃 可通过铑催化反应制备 N-烯基丙烷-1,3-二胺和 2-(烯氨基)乙醇与 H2/CO 发生铑催化反应，可以制备含有中环和大环的 收率极高，无需高度稀释。这些化合物的选择性开环 可生成大型杂环。

  DOI：

  10.1071/ch99097

文献信息

• High yields of diazabicycloalkanes and oxazabicycloalkanes containing medium and large rings from rhodium-catalysed hydroformylation reactions without the need for high dilution conditions
  作者：David J. Bergmann、Eva M. Campi、W. Roy Jackson、Antonio F. Patti

  DOI：10.1039/a903638e

  日期：——

  Rhodium-catalysed reactions of N-alkenyl-1,3-diaminopropanes and N-alkenylaminoethanols give diazabicycloalkanes and oxazabicycloalkanes containing medium or large rings in excellent yields.

  铑催化的N-烯基-1,3-二胺丙烷和N-烯基氨基乙醇反应能高产率地生成含有中环或大环的二氮双环烷烃和氧氮双环烷烃。
• Photoactivable nitrogen bases
  申请人：——

  公开号：US20040242867A1

  公开（公告）日：2004-12-02

  Compounds of the formula I R7″N—R6 RS—C,N—R4 H C, R′/I R, 3 R 2 (I) in which R, is an aromatic or heteroaromatic radical which is capable of absorbing light in the wave-length range from 200 nm to 650 nm and which is unsubstituted or substituted one or more times by C,—C,8alkyl, C2-C,ealkenyl, C2-C,8alkynyl, C,—C,ehaloalkyl, NO2, NR,OR, CN, OR,2, SR,2, C(O)R,3, C(O)OR,4, halogen or a radical of the formula II R˜—N′ R6 1 R5-C,N.R4 H I C—R3 I R2 (E) and which on absorption brings about a photoelimination which leads to the generation of an amidine group, R2 and R3 independently of one another are hydrogen, C,—C,ealkyl or phenyl which is unsubstituted or is substituted one or more times by C,—C,8alkyl, CN, OR,2, SR,2, halogen or C,—C,ehaloalkyl; R5 is C,—C,ealkyl or NR8R9; R4, R6, R, R8, R9, R,o and R inde-pendently of one another are hydrogen or C,—C,8alkyl; or R4 and R6 together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; or R5 and R, independently of R4 and R6, together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; or, if R5 is a radi-cal NR8R9, R, and R9 together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; and R,2, R,3 and R,4 independently of one another are hydrogen or C,—C,ealkyl; are suitable as photoinitiators for compounds which react under base catalysis. 1

  公式I中的化合物，其中R，是一种芳香或杂芳基团，能够在200nm至650nm的波长范围内吸收光，并且未被取代或被C,-C,8烷基，C2-C,e烯基，C2-C,8炔基，C,-C,卤代烷基，NO2，NR，OR，CN，OR,2，SR,2，C(O)R,3，C(O)OR,4，卤素或公式II R' -N' R6 1 R5-C，N.R4 H I C-R3 I R2（E）取代一次或多次，吸收后引起光消除，导致产生酰胺基团，其中R2和R3独立地是氢，C,-C,e烷基或苯基，未被取代或被C,-C,8烷基，CN，OR,2，SR,2，卤素或C,-C,卤代烷基取代；R5是C,-C,e烷基或NR8R9；R4，R6，R，R8，R9，R,o和R独立地是氢或C,-C,8烷基；或R4和R6共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；或R5和R，独立于R4和R6，共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；或者，如果R5是一个基团NR8R9，R，和R9共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；而R,2，R,3和R,4独立地是氢或C,-C,e烷基；适用于在碱催化下反应的化合物的光引发剂。
• Letter with continuation application
  申请人：Baudin Gisele

  公开号：US20090076200A1

  公开（公告）日：2009-03-19

  Base-polymerizable or base-crosslinkable compositions comprising select bicyclic amines with benzylic substitution undergo photochemically induced, base-catalysed reactions upon photochemical conversion of the benzylically substituted amine to an amidine derivative.

  含有选择的苯基取代双环胺的基团可聚合或交联的组合物，在苯基取代胺光化学转化为酰胺衍生物时，经光化学诱导和碱催化反应。
• CURABLE-ON-DEMAND COMPOSITION COMPRISING DUAL REACTIVE SILANE FUNCTIONALITY
  申请人：Yang Yu

  公开号：US20130178553A1

  公开（公告）日：2013-07-11

  A curable composition comprises (a) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydrosilyl moiety; (b) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydroxysilyl moiety, the hydroxysilyl moiety optionally being generated in situ by hydrolysis of at least one hydrosilyl moiety; and (c) at least one photoactivatable composition that, upon exposure to radiation, generates at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; with the proviso that, when component (a) is an organic polymer, then component (b) is different from component (a) and is not generated in situ by hydrolysis of component (a).

  一种可治愈的组合物包括：（a）至少一种含有反应性硅烷官能团的无机或有机化合物，其中硅烷官能团包括至少一个氢硅烷基；（b）至少一种含有反应性硅烷官能团的无机或有机化合物，其中硅烷官能团包括至少一个羟基硅烷基，羟基硅烷基可以通过至少一个氢硅烷基的水解而在原位生成；以及（c）至少一种光活性组合物，当暴露于辐射下时，生成至少一种从氨基甲酸酰胺、鸟嘌呤、磷氮烷、丙氨酸磷酸酯和其组合物中选择的碱，前提是当组分（a）是有机聚合物时，组分（b）与组分（a）不同，并且不是通过组分（a）的水解在原位生成的。
• CURABLE-ON-DEMAND POLYSILOXANE COATING COMPOSITION
  申请人：Yang Yu

  公开号：US20130101841A1

  公开（公告）日：2013-04-25

  A curable composition comprises (a) at least one polydiorganosiloxane, fluorinated polydiorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydroxysilyl moieties; (b) at least one polydiorganosiloxane, fluorinated polydiorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydrosilyl moieties; and (c) at least one photoactivatable composition that, upon exposure to radiation, generates at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; wherein at least one of the components (a) and (b) has an average reactive silane functionality of at least three.

  可治疗组合物包括：(a)至少一种聚二甲基硅氧烷、氟代聚二甲基硅氧烷或二者的组合物，其包含具有至少两个羟基硅基的反应性硅烷官能团；(b)至少一种聚二甲基硅氧烷、氟代聚二甲基硅氧烷或二者的组合物，其包含具有至少两个氢硅基的反应性硅烷官能团；以及(c)至少一种光致活性组分，当暴露于辐射下时，会产生从氨基化合物、胍化合物、磷氮化合物、脲基磷杂环丙烷和它们的组合物中选择的至少一种碱；其中，组分(a)和/或(b)中至少有一种的平均反应性硅烷官能团为至少三个。