cis-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid
• 英文别名: (3R,4R)-3-(4-bromophenyl)-2-(2,4-dichlorophenyl)-4-methyl-3,4-dihydropyrazole-5-carboxylic acid
• 化学式: C₁₇H₁₃BrCl₂N₂O₂
• 分子量: 428.112
• InChiKey: BHBQAOSGKGJCIR-XXFAHNHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-4-(4-chlorophenyl)-3-methyl-2-oxo-but-3-enoic acid 、 2,4-二氯苯肼 以 溶剂黄146 为溶剂， 反应 2.0h， 以46%的产率得到cis-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid
  参考文献：
  名称：

  Active substance combination for the treatment of diabetes

  摘要：

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，用于治疗糖尿病，包括该活性物质组合的药物、包括该活性物质组合的制药配方以及利用该活性物质组合制造药物的用途。

  公开号：

  EP1946778A1

文献信息

• Substituted pyrazoline for preventing weight gain
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946777A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, known to produce weight-gain as a side effect, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，该药物以体重增加作为副作用而知名，包括所述活性物质组合的药物、包括所述活性物质组合的药物制剂、以及利用所述活性物质组合制造药物。
• 4-Substituted Pyrazoline Compounds, their Preparation and Use as Medicaments
  申请人：TORRENS Antoni

  公开号：US20070073056A1

  公开（公告）日：2007-03-29

  The present invention relates to 4-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及4-取代吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• Octahydropentalene-Substituted Pyrazoline Derivatives, Their Prepartion and Use as Medicaments
  申请人：Torrens Jover Antonio

  公开号：US20090054509A1

  公开（公告）日：2009-02-26

  The present invention relates to octahydropentalene-substituted pyrazoline compounds of formula I, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. (1)

  本发明涉及式I的八氢松环戊二烯取代的吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。(1)
• Azepane- or Azocane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments
  申请人：Torrens Jover Antonio

  公开号：US20080269201A1

  公开（公告）日：2008-10-30

  The present invention relates to Azepane- or Azocane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals

  本发明涉及公式（I）的氮杂环庚烷或氮杂环庚烷取代的吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• Cycloalkane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments
  申请人：Torrens Jover Antonio

  公开号：US20080293797A1

  公开（公告）日：2008-11-27

  The present invention relates to Cycloalkane-substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及Cycloalkane-取代的吡唑烷化合物的化学式（I），其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。