5',9-anhydro-8-chloro-3-(β-D-ribofuranosyl)xanthine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 5',9-anhydro-8-chloro-3-(β-D-ribofuranosyl)xanthine
• 英文别名: (9R,10R,11S,12R)-2-chloro-10,11-dihydroxy-15-oxa-1,3,6,8-tetrazatetracyclo[6.5.1.19,12.04,14]pentadeca-2,4(14)-diene-5,7-dione
• 化学式: C₁₀H₉ClN₄O₅
• 分子量: 300.658
• InChiKey: BJSUCWPIYDOLSW-UMMCILCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5',9-anhydro-2',3'-O-isopropylidene-iso xanthosine 在 N-氯代丁二酰亚胺 、 溶剂黄146 、 三氟乙酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 生成 5',9-anhydro-8-chloro-3-(β-D-ribofuranosyl)xanthine
  参考文献：
  名称：

  Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents

  摘要：

  In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.

  DOI：

  10.1080/15257770601052307

文献信息

• Synthesis and Biological Activity of 5′,9-Anhydro<i>-</i>3-Purine-<i>ISO</i>Nucleosides as Potential Anti-Hepatitis C Virus Agents
  作者：Byoung-Kwon Chun、Peiyuan Wang、Abdalla Hassan、Jinfa Du、Phillip M. Tharnish、Eisuke Murakami、Lieven Stuyver、Michael J. Otto、Raymond F. Schinazi、Kyoichi A. Watanabe

  DOI：10.1080/15257770601052307

  日期：2007.1

  In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.