Sapunifiram | 577778-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Sapunifiram
• 英文别名: MN19；N-[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]acetamide
• CAS: 577778-29-1
• 化学式: C₁₃H₁₇FN₂O₃S
• 分子量: 300.354
• InChiKey: BKXONLCLMIKFNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-乙酰氨基-1-苄基哌啶 在 palladium on activated charcoal 、 甲酸铵 、 三乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 Sapunifiram
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2

文献信息

• 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
  作者：Dina Manetti、Elisabetta Martini、Carla Ghelardini、Silvia Dei、Nicoletta Galeotti、Luca Guandalini、Maria Novella Romanelli、Serena Scapecchi、Elisabetta Teodori、Alessandro Bartolini、Fulvio Gualtieri

  DOI：10.1016/s0960-894x(03)00437-2

  日期：2003.7

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.