N,N-Dibutyl-2-p-tolyl-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-Dibutyl-2-p-tolyl-acetamide
• 英文别名: N,N-dibutyl-2-(4-methylphenyl)acetamide
• 化学式: C₁₇H₂₇NO
• 分子量: 261.407
• InChiKey: BMVWFYXVJMDCIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴-N,N-二丁基乙酰胺 、 4-甲苯硼酸 在 四(三苯基膦)钯 copper(I) oxide 、 potassium phosphate 、 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以76%的产率得到N,N-Dibutyl-2-p-tolyl-acetamide
  参考文献：
  名称：

  Palladium-catalyzed synthesis of arylacetamides from arylboronic acids

  摘要：

  Aryl amides were synthesized by the palladium catalyzed cross-coupling reaction of alpha-bromoacetamides with arylboronic acids in good yields. Both electron-donating and electron-withdrawing substituents on the aromatic ring are found to be compatible. The addition of Cu2O and PPh3 was found to be essential for good reaction yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00586-0

文献信息

• Palladium-catalyzed synthesis of arylacetamides from arylboronic acids
  作者：Ya-Zhen Duan、Min-Zhi Deng

  DOI：10.1016/s0040-4039(03)00586-0

  日期：2003.4

  Aryl amides were synthesized by the palladium catalyzed cross-coupling reaction of alpha-bromoacetamides with arylboronic acids in good yields. Both electron-donating and electron-withdrawing substituents on the aromatic ring are found to be compatible. The addition of Cu2O and PPh3 was found to be essential for good reaction yields. (C) 2003 Elsevier Science Ltd. All rights reserved.