(S)-ethyl 2-benzyloxycarbonylamino-6-hydroxy-2-hydroxymethylhexanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-ethyl 2-benzyloxycarbonylamino-6-hydroxy-2-hydroxymethylhexanoate
• 英文别名: ethyl (2S)-6-hydroxy-2-(hydroxymethyl)-2-(phenylmethoxycarbonylamino)hexanoate
• 化学式: C₁₇H₂₅NO₆
• 分子量: 339.389
• InChiKey: BNFVEGSNMRLXBK-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (R)-1-ethoxycarbonyl-2-cyclohexene-1-carboxylic acid 在 sodium tetrahydroborate 、 叠氮磷酸二苯酯 、 臭氧 、 三乙胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 24.5h， 生成 (S)-ethyl 2-benzyloxycarbonylamino-6-hydroxy-2-hydroxymethylhexanoate
  参考文献：
  名称：

  Chemoenzymatic synthesis of an α-substituted serine derivative

  摘要：

  An asymmetric synthesis of an alpha-substituted serine derivative was achieved by employing PLE-catalyzed hydrolysis of a prochiral malonate derivative, and the absolute configuration of the hydrolyzed product was unambiguously determined by the X-ray analysis of a camphorsulfonic acid derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00270-0

文献信息

• Chemoenzymatic synthesis of an α-substituted serine derivative
  作者：Toshio Honda、Tatsuya Koizumi、Yuki Komatsuzaki、Rie Yamashita、Kazuo Kanai、Hiromasa Nagase

  DOI：10.1016/s0957-4166(99)00270-0

  日期：1999.7

  An asymmetric synthesis of an alpha-substituted serine derivative was achieved by employing PLE-catalyzed hydrolysis of a prochiral malonate derivative, and the absolute configuration of the hydrolyzed product was unambiguously determined by the X-ray analysis of a camphorsulfonic acid derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.