1,1-bis(4-fluorophenyl)propanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-bis(4-fluorophenyl)propanol
• 英文别名: 1,1-bis(4-fluorophenyl)propan-1-ol
• 化学式: C₁₅H₁₄F₂O
• 分子量: 248.272
• InChiKey: GDVVSJGMNOGXCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-bis(4-fluorophenyl)propanol 在 对甲苯磺酸一水合物 作用下， 以 甲苯 为溶剂， 以2.39 g (92%)的产率得到1-氟-4-[1-(4-氟苯基)丙-1-烯基]苯
  参考文献：
  名称：

  2,2 (Diarlyl) Vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst

  摘要：

  一种由以下通用公式（1）表示的新型2,2-(二芳基)乙烯膦化合物：其中R1是氢原子、具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等；R2、R3、R4、R5、R6和R7可能相同或不同，每个是具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等，但要求R4和R5一起和/或R6和R7一起可能代表融合苯环、取代融合苯环、三亚甲基基团等；p、q、r和s每个为0至5，但要求p+q和r+s分别在0至5的范围内；通过使钯化合物作用于新型2,2-(二芳基)乙烯膦化合物而获得的钯-膦催化剂；以及在钯-膦催化剂存在下获得芳胺、二芳基和芳基炔的方法。

  公开号：

  US20020058837A1
• 作为产物：
  描述：

  乙基氯化镁 、 4,4'-二氟二苯甲酮 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 22.33h， 以78%的产率得到1,1-bis(4-fluorophenyl)propanol
  参考文献：
  名称：

  2,2-(Diaryl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst

  摘要：

  公开号：

  EP1167372B1

文献信息

• [EN] PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY<br/>[FR] COMPOSÉS PICOLINAMIDE À ACTIVITÉ FONGICIDE
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2016122802A1

  公开（公告）日：2016-08-04

  This disclosure relates to picolinamides of Formula I and their use as fungicides. Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.

  本公开涉及公式I的吡啶酰胺及其作为杀菌剂的使用。杀菌剂是天然或合成来源的化合物，作用是保护植物并/或治愈由农业相关真菌造成的损害。通常，没有一种杀菌剂在所有情况下都有效。因此，研究正在进行中，以生产可能具有更好性能、更易于使用且成本更低的杀菌剂。
• Asymmetric Addition of Arylboronic Acids to Cumulene Derivatives Catalyzed by Axially Chiral N-Heterocyclic Carbene-Pd2+ Complexes
  作者：Zhen Liu、Peng Gu、Min Shi

  DOI：10.1002/chem.201100703

  日期：2011.5.16

  Cumulene+carbene=chirality! Asymmetric additions of boronic acids to cumulene derivatives, catalyzed by an N‐heterocyclic carbene–palladium complex, provide the desired allenic products in good to excellent yields and moderate to good enantioselectivities. These optically active allenic adducts can be further transformed to useful chiral products in good yields and with an intact chirality (see scheme)

  异丙苯+卡宾=手性！N杂环卡宾-钯络合物催化将硼酸不对称地添加到异丙苯衍生物中，可提供所需的烯丙基产物，其收率良好至优异，对映选择性中等至良好。这些光学活性的烯丙基加合物可以以高收率和完整的手性被进一步转化为有用的手性产物（参见方案）。
• 2,2 (Diarlyl) Vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst
  申请人：——

  公开号：US20020058837A1

  公开（公告）日：2002-05-16

  A novel 2,2-(diaryl)vinylphosphine compound represented by the following general formula (1): 1 (wherein R 1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc.; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 may be the same or different and each is an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc., provided that R 4 and R 5 taken together and/or R 6 and R 7 taken together may represent a fused benzene ring, a substituted fused benzene ring, a trimethylene group, etc.; and p, q, r, and s each is 0 to 5, provided that p+q and r+s each is in the range of from 0 to 5); a palladium-phosphine catalyst obtained by causing a palladium compound to act on the novel 2,2-(diaryl)vinylphosphine compound; and a process for obtaining an arylamine, a diaryl and an arylalkyne in the presence of the palladium-phosphine catalyst.

  一种由以下通用公式（1）表示的新型2,2-(二芳基)乙烯膦化合物：其中R1是氢原子、具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等；R2、R3、R4、R5、R6和R7可能相同或不同，每个是具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等，但要求R4和R5一起和/或R6和R7一起可能代表融合苯环、取代融合苯环、三亚甲基基团等；p、q、r和s每个为0至5，但要求p+q和r+s分别在0至5的范围内；通过使钯化合物作用于新型2,2-(二芳基)乙烯膦化合物而获得的钯-膦催化剂；以及在钯-膦催化剂存在下获得芳胺、二芳基和芳基炔的方法。
• 2,2(diarlyl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst
  申请人：Takasago International Corporation

  公开号：US06455720B1

  公开（公告）日：2002-09-24

  A novel 2,2-(diaryl)vinylphosphine compound represented by the following general formula (1): (wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc.; R2, R3, R4, R5, R6, and R7 may be the same or different and each is an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc., provided that R4 and R5 taken together and/or R6 and R7 taken together may represent a fused benzene ring, a substituted fused benzene ring, a trimethylene group, etc.; and p, q, r, and s each is 0 to 5, provided that p+q and r+s each is in the range of from 0 to 5); a palladium-phosphine catalyst obtained by causing a palladium compound to act on the novel 2,2-(diaryl)vinylphosphine compound; and a process for obtaining an arylamine, a diaryl and an arylalkyne in the presence of the palladium-phosphine catalyst.

  下列通用式（1）所代表的新型2,2-(二芳基)乙烯基膦化合物：（其中R1为氢原子、具有1至6个碳原子的烷基、具有5至7个碳原子的脂环族基等；R2、R3、R4、R5、R6和R7可以相同也可以不同，每个都是具有1至6个碳原子的烷基、具有5至7个碳原子的脂环族基等，前提是R4和R5共同取代和/或R6和R7共同取代可以表示为融合苯环、取代融合苯环、三亚甲基基团等；p、q、r和s每个都为0至5，前提是p+q和r+s每个都在0至5的范围内）；由于将钯化合物作用于新型2,2-(二芳基)乙烯基膦化合物而获得的钯膦催化剂；以及在钯膦催化剂的存在下获得芳胺、二芳基和芳基炔的过程。
• Fungicidal triazoleethanols
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0137718A2

  公开（公告）日：1985-04-17

  Compounds of formula wherein X1, X2, Y1 and Y2 are independently H, F. or Cl, with the proviso that at least one of X1, X2, Y1 and Y2 is F or Cl; or fungicidally active salts of compounds of Formula I with protic acids or complexes of compounds of Formula I with metal ions; exhibit potent fungical activity. The novel compounds may be used to control fungal disease in plants by foliar application, soil application, or as a seed dressing. The novel compounds may be made by reacting an appropriate 2-halo-1,1-diaryl-1-propanol or 1,1-diaryl-1-propylene oxide with 1,2,4-triazole.

  式中的化合物 式中 X1、X2、Y1 和 Y2 独立地为 H、F. 或 Cl，但至少 X1、X2、Y1 和 Y2 中至少有一个是 F 或 Cl；或式 I 化合物与原酸的杀真菌活性盐或式 I 化合物与金属离子的络合物； 具有强大的杀真菌活性。 新型化合物可通过叶面施用、土壤施用或作为拌种剂用于控制植物的真菌疾病。 新型化合物可通过适当的 2-卤基-1,1-二芳基-1-丙醇或 1,1-二芳基-1-环氧丙烷与 1,2,4-三唑反应制成。