(E)-2,4-difluoro-1-styrylbenzene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-2,4-difluoro-1-styrylbenzene
• 英文别名: 2,4-difluoro-1-[(E)-2-phenylethenyl]benzene
• 化学式: C₁₄H₁₀F₂
• 分子量: 216.23
• InChiKey: ZCOQLHWTUQGGEU-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-2,4-difluoro-1-styrylbenzene 在 重水 、 potassium ethyl xanthogenate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以79%的产率得到(E)-2,4-difluoro-1-(2-phenylvinyl-1,2-d₂)benzene
  参考文献：
  名称：

  通过黄药介导的氢-氘交换反应合成氘 (E)-烯烃

  摘要：

  在此，我们开发了非活化烯烃的可逆氢-氘交换反应。以EtOCS 2 K为介体，通过反复加成和消去反应实现H/D交换反应，证明了普通烯烃和氘化烯烃之间的H/D交换是可逆的。在没有贵金属催化剂和配体的情况下使用最低成本的 D 2 O，实现了广泛的官能团兼容性。

  DOI：

  10.1021/acs.orglett.1c02600
• 作为产物：
  描述：

  2,4-二氟苯甲醛 在 喹啉 、 chromium(III) oxide 、 乙酸酐 、 三乙胺 、 copper(II) oxide 作用下， 反应 2.0h， 生成 (E)-2,4-difluoro-1-styrylbenzene
  参考文献：
  名称：

  Synthesis and biological evaluation of 1,1-Dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents

  摘要：

  Z-1,1-Dichloro-2,3-diphenylcyclopropane (1) is an effective 'anti-breast cancer agent in rodents and in cell culture. We recently determined that 1 inhibits tubulin assembly in vitro. and causes microtubule loss in breast cancer cells, leading to accumulation in the G2/M portion of the cell cycle. Aryl ring-halogenated, methoxylated and benzyloxylated derivatives of 1, as well as its E-isomer and the dichlorocyclopropyl derivative of diethylstilbestrol (DES), were synthesized and tested for their ability to inhibit the assembly of tubulin into micro tubules. Including 1, 17 cyclopropyl compounds were tested. One (Z-1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane (12)) was found to be more active than 1. In addition, E-1,1-dichlorocyclopropylDES (17) was more potent than DES. The E-isomer of 1 (16) was inactive. The cytostatic activities of the compounds against MCF-7 and MDA-MB231 human breast cancer cells, and their abilities to perturb microtubules in MCF-7 cells were also evaluated. Z-Dichloro-2-(4-fluorophenyl)-3-phenylcyclo (5), Z-1,1-dichloro-2-(4-fluorophenyl)-3-(4-methoxyphenyl)cyclopropane (11), and Z-1,1-dichloro-2-(4-methoxyphenyl) -3-phenylcyclopropane (12) were more potent than 1 against the breast cancer cells. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00014-x

文献信息

• Cross-Coupling Catalysis by an Anionic Palladium Complex
  作者：Felix Schroeter、Johannes Soellner、Thomas Strassner

  DOI：10.1021/acscatal.6b03655

  日期：2017.4.7

  Recent studies have shown that anionic palladium complexes are viable catalysts for a range of catalytic cross-coupling reactions. We present a one-step synthesis of the anionic “ligandless” palladium complex [NBu4][Pd(DMSO)Cl3] together with its crystal structure. This compound has been shown to be an active precatalyst in the Mizoroki–Heck reaction. Under Jeffery conditions, activated aryl chlorides

  最近的研究表明，阴离子钯络合物是用于一系列催化交叉偶联反应的可行催化剂。我们目前一步一步合成阴离子“无配体”钯络合物[NBu 4 ] [Pd（DMSO）Cl 3 ]及其晶体结构。该化合物已被证明是Mizoroki-Heck反应中的活性预催化剂。在杰弗里条件下，活化的芳基氯化物可以偶联，收率高达94％，而无需其他配体。少量水的存在对于产物形成是必需的。Amatore-Jutand型催化循环与本文介绍的结果一致。为了与已知的混合配合物[（pym-Im-Me）2 PdCl] [Pd（DMSO）Cl 3]，已使用标准技术合成并表征了阳离子络合物[（pym-Im-Me）2 PdCl] PF 6（pym =嘧啶基，Im =咪唑啉-2-亚基）。
• Biogenic synthesis of Pd-nanoparticles using Areca Nut Husk Extract: a greener approach to access α-keto imides and stilbenes
  作者：Rajeev V. Hegde、Arnab Ghosh、Arvind H. Jadhav、Aatika Nizam、Siddappa A. Patil、Febina Peter、Ramesh B. Dateer

  DOI：10.1039/d1nj02858h

  日期：——

  An eco-friendly green method for a one-step synthesis of palladium nanoparticles and their synthetic utility are reported. Phytochemicals like amines, alcohols, and phenols present in the Areca Nut Husk extract facilitate the reduction of Pd(II) to Pd(0). The phytochemicals serve as stabilising agents and ligands for palladium reduction and the need for an external ligand is avoided. The Field Emission

  报告了一种用于一步合成钯纳米颗粒的环保绿色方法及其合成效用。槟榔果壳提取物中的胺类、醇类和酚类等植物化学物质有助于减少 Pd( II) 到 Pd(0)。植物化学物质用作钯还原的稳定剂和配体，并且避免了对外部配体的需要。新合成的钯纳米粒子的场发射扫描电子显微镜和透射电子显微镜显示出球形形态。测试了纳米颗粒的催化活性，用于 ynamides 的 1,2-双官能化、Heck 偶联、苯肼的脱氮偶联和吲哚的 C-H 芳基化。此外，还详细阐述了催化剂的可回收性、控制实验、机理阐明和克级合成。
• Synthesis of (E)-Stilbenes and (E,E)-1,4-Diphenylbuta-1,3-diene Promoted by Boron Trifluoride-Diethyl Ether Complex
  作者：T. Narender、K. Papi Reddy、G. Madhur

  DOI：10.1055/s-0029-1217010

  日期：2009.11

  developed to regioselectively synthesize (E)-stilbenes and (E,E)-1,4-diphenylbuta-1,3-diene in good to excellent yields in the presence of boron trifluoride-diethyl ether complex as a catalyst in a short reaction (30-60 s) at room temperature. boron trifluoride-diethyl ether complex - (E)-stilbenes - (E,E)-1,4-diphenylbuta-1,3-diene - ketones - regioselectivity

  已经开发了一种有效，简单且实用的方法，可以在三氟化硼-二乙基硼的存在下，以良好至极佳的收率选择性地合成（E）-苯乙烯和（E，E）-1,4-二苯基丁a -1,3-二烯。室温下短时间反应（30-60 s）中作为醚配合物的催化剂。 三氟化硼-乙醚复合物-（E）-对苯二酚-（E，E）-1,4-二苯基丁a -1,3-二烯-酮-区域选择性
• AROMATIC HYDROCARBON-BASE PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP1826846A1

  公开（公告）日：2007-08-29

  A proton exchange membrane is obtained which can give an excellent power generation characteristic when the membrane is applied to, in particular, a fuel cell wherein high-concentration methanol is used as a fuel. In the aromatic hydrocarbon based proton exchange membrane of the invention, the ion exchange capacity is set into the range of 0.6 to 1.3 meq/g. Moreover, the area swelling rate for a 30% by mass methanol aqueous solution at 40°C is set into the range of 2 to 30%. Preferably, a sulfonic acid group is bonded to an aromatic ring of the aromatic hydrocarbon based polymer contained in the aromatic hydrocarbon based proton exchange film. Preferably, the aromatic hydrocarbon based polymer is a polyarylene ether based polymer.

  本发明获得了一种质子交换膜，当将该膜应用于燃料电池，特别是使用高浓度甲醇作为燃料的燃料电池时，该膜可提供出色的发电特性。在本发明的芳香烃基质子交换膜中，离子交换容量设定在 0.6 至 1.3 meq/g 的范围内。此外，在 40°C 时，质量分数为 30% 的甲醇水溶液的面积膨胀率设定为 2% 至 30%。优选地，磺酸基与芳香烃基质子交换膜中所含芳香烃基聚合物的芳香环键合。芳香烃基聚合物最好是聚芳醚基聚合物。
• SULFONIC ACID GROUP-CONTAINING POLYMER, METHOD FOR PRODUCING SAME, RESIN COMPOSITION CONTAINING SUCH SULFONIC ACID GROUP-CONTAINING POLYMER, POLYMER ELECTROLYTE MEMBRANE, POLYMER ELECTROLYTE MEMBRANE/ELECTRODE ASSEMBLY, AND FUEL CELL
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP1889863A1

  公开（公告）日：2008-02-20

  The present invention relates to a sulfonic acid group-containing polymer excellent in ion conductivity and durability, a method for producing the same, a resin composition containing the sulfonic acid group-containing polymer, a polymer electrolyte membrane, a polymer electrolyte membrane/electrode assembly, and a fuel cell. The sulfonic acid group-containing polymer of the present invention, in a first embodiment, includes a constituent represented by the following chemical formula 1: wherein X represents hydrogen or a monovalent cation species; Y represents a sulfone group or a ketone group; and n represents an arbitrary integer not less than 2.

  本发明涉及一种离子传导性和耐久性极佳的含磺酸基聚合物、其生产方法、含有该含磺酸基聚合物的树脂组合物、聚合物电解质膜、聚合物电解质膜/电极组件和燃料电池。在第一个实施方案中，本发明的含磺酸基聚合物包括由以下化学式表示的成分 1： 其中 X 代表氢或一价阳离子种类；Y 代表砜基或酮基；n 代表不小于 2 的任意整数。