2-(2,3-dimethoxyphenyl)-4,6-diphenyl-1,2-dihydro-1,3,5-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,3-dimethoxyphenyl)-4,6-diphenyl-1,2-dihydro-1,3,5-triazine
• 英文别名: 4-(2,3-Dimethoxyphenyl)-2,6-diphenyl-1,4-dihydro-1,3,5-triazine；4-(2,3-dimethoxyphenyl)-2,6-diphenyl-1,4-dihydro-1,3,5-triazine
• 化学式: C₂₃H₂₁N₃O₂
• 分子量: 371.439
• InChiKey: JOUHGSBMZDYTAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.21
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  苯甲脒 、 2,3-二甲氧基苯甲醛 在 sodium sulfate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 以89%的产率得到2-(2,3-dimethoxyphenyl)-4,6-diphenyl-1,2-dihydro-1,3,5-triazine
  参考文献：
  名称：

  MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines

  摘要：

  A tunable microwave-assisted protocol for the synthesis of two biologically relevant families of heterocycles has been designed. Via a simple switch of reaction conditions, the same starting materials can be engaged in either an improved synthesis of the dihydrotriazine scaffold or a novel, first-in-class MCR to render the challenging 5-aminoimidazole nucleus in a single step. An additional first-in-class MCR is also reported utilizing guanidines to afford 2,5-aminoimidazoles. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.035

文献信息

• MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines
  作者：Christan E. Bell、Arthur Y. Shaw、Fabio De Moliner、Christopher Hulme

  DOI：10.1016/j.tet.2013.11.035

  日期：2014.1

  A tunable microwave-assisted protocol for the synthesis of two biologically relevant families of heterocycles has been designed. Via a simple switch of reaction conditions, the same starting materials can be engaged in either an improved synthesis of the dihydrotriazine scaffold or a novel, first-in-class MCR to render the challenging 5-aminoimidazole nucleus in a single step. An additional first-in-class MCR is also reported utilizing guanidines to afford 2,5-aminoimidazoles. (C) 2013 Elsevier Ltd. All rights reserved.