9-(1,3-dihydroxy propoxymethyl) guanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(1,3-dihydroxy propoxymethyl) guanine
• 英文别名: ganciclovir；9-[1,3-Dihydroxypropoxymethyl]guanine；2-amino-9-(1,3-dihydroxypropoxymethyl)-1H-purin-6-one
• 化学式: C₉H₁₃N₅O₄
• 分子量: 255.233
• InChiKey: RYPRLBQTBQNMJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  9-(1,3-dihydroxy propoxymethyl) guanine 、 L-缬氨酸 、 氯甲酸苄酯 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以66%的产率得到2-((2-amino-1, 6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-1,3-propanediyl bis(N-(benzyloxy) carbonyl)-l-valinate
  参考文献：
  名称：

  Protease-mediated preparation of valganciclovir intermediate

  摘要：

  DOI：

  10.1016/j.molcatb.2014.07.004

文献信息

• Pharmaceutical compositions for the treatment of diseases caused by viruses
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：EP0270317A2

  公开（公告）日：1988-06-08

  A pharmaceutical composition for treating a disease caused by virus comprising (A) an antiviral agent lacking inhibitory activity (1) against a cell-to-cell infection through cell fusion from a virus infected cell to an uninfected cell and/or (2) against adsorption of a virus to a target cell, and (B) a compound possessing cell fusion inhibitory activity and/or virus-adsorption inhibitory activity, said antiviral agent and compound being administered in respective amounts so that the combined dosage thereof is effective to treat said disease.

  一种用于治疗由病毒引起的疾病的药物组合物，包括 (A) 抗病毒剂，该抗病毒剂缺乏以下抑制活性：(1)通过从病毒感染细胞到未感染细胞的细胞融合抑制细胞间感染和/或(2)抑制病毒吸附到靶细胞，以及 (B) 具有细胞融合抑制活性和/或病毒吸附抑制活性的化合物、 所述抗病毒剂和化合物以各自的量给药，使其组合剂量能有效治疗所述疾病。
• Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0375329A2

  公开（公告）日：1990-06-27

  The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment and prophylaxis of herpes virus infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.

  本发明涉及含有无环侧链的嘧啶和嘌呤核苷的氨基酸酯及其在医学治疗中的用途，特别是疱疹病毒感染的治疗和预防。此外，还提供了根据本发明制备化合物的药物制剂和工艺。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

  公开号：EP0269947B2

  公开（公告）日：1996-10-16
• Treatment of diseases caused by viruses
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：EP0312222B1

  公开（公告）日：1992-08-05