fluorenespiro[9.3']-4'-(p-methoxyphenyl)tetrahydropyrrolo[1,2-c]thiazolespiro[2'.2'']indan-1'',3''-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluorenespiro[9.3']-4'-(p-methoxyphenyl)tetrahydropyrrolo[1,2-c]thiazolespiro[2'.2'']indan-1'',3''-dione
• 化学式: C₃₃H₂₅NO₃S
• 分子量: 515.632
• InChiKey: YRFSETWOAGPTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  71.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  水合茚三酮 、 p-methoxybenzylidene fluorene 、 噻莫西酸 反应 3.7h， 以90%的产率得到fluorenespiro[9.3']-4'-(p-methoxyphenyl)tetrahydropyrrolo[1,2-c]thiazolespiro[2'.2'']indan-1'',3''-dione
  参考文献：
  名称：

  Microwave induced one-pot synthesis of fluorenespiro[9.3′]-(4′-aryl)pyrrolidine/pyrrolizidine/tetrahydropyrrolo[1,2-c]thiazolespiro[2′.2″]indan-1″,3″-dione derivatives

  摘要：

  A versatile one-pot method for the synthesis of new dispiro heterocycles is described using an intermolecular [3+2] cycloaddition reaction. The reaction gives excellent yields when carried out under solvent-free microwave irradiation. (c) 2006 Elsevier Ltd. All fights reserved.

  DOI：

  10.1016/j.tet.2006.09.105

文献信息

• Microwave induced one-pot synthesis of fluorenespiro[9.3′]-(4′-aryl)pyrrolidine/pyrrolizidine/tetrahydropyrrolo[1,2-c]thiazolespiro[2′.2″]indan-1″,3″-dione derivatives
  作者：Rathna Durga R.S. Manian、Jayadevan Jayashankaran、Raghavachary Raghunathan

  DOI：10.1016/j.tet.2006.09.105

  日期：2006.12

  A versatile one-pot method for the synthesis of new dispiro heterocycles is described using an intermolecular [3+2] cycloaddition reaction. The reaction gives excellent yields when carried out under solvent-free microwave irradiation. (c) 2006 Elsevier Ltd. All fights reserved.