N-acryloylsuccinimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-acryloylsuccinimide
• 英文别名: 1-prop-2-enoylpyrrolidine-2,5-dione
• 化学式: C₇H₇NO₃
• 分子量: 153.137
• InChiKey: RCJRCAFDVCTPLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2’,3’邻异亚丙基尿苷 、 N-acryloylsuccinimide 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 以69%的产率得到5'-O-acryloyl-2',3'-O-isopropylideneuridine
  参考文献：
  名称：

  First synthesis of a dihydroorotidine analogue via a diastereoselective [2+2] photocycloaddition

  摘要：

  The first synthesis of a dihydroorotidine analogue via [2+2] photocycloaddition is described. The product is a potential inhibitor of the orotidine-5'-phosphate decarboxylase enzyme. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2003.11.019

文献信息

• METHOD FOR IMMOBILIZING BIOLOGIC MOLECULES ON SOLID SURFACES
  申请人：CHIARI Marcella

  公开号：US20150087555A1

  公开（公告）日：2015-03-26

  The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support.

  这项发明提供了一种将生物分子（如核酸、肽和蛋白质）固定在玻璃或塑料固体支持物表面的方法。
• Polyacrylamides Bearing Pendant α-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza Virus:  The Strong Inhibition Reflects Enhanced Binding through Cooperative Polyvalent Interactions
  作者：George B. Sigal、Mathai Mammen、Georg Dahmann、George M. Whitesides

  DOI：10.1021/ja953729u

  日期：1996.4.24

  An ELISA assay is described for measuring the binding of influenza virus A-X31 to α-sialoside groups that are linked to biotin-labeled polyacrylamides. The efficacy of these polymers in inhibiting the adhesion of influenza virus to erythrocytes (as measured by a hemagglutination assay) was shown to be directly related to the binding affinity of the polymers for the viral surface: the differences in

  描述了一种 ELISA 检测方法，用于测量流感病毒 A-X31 与连接到生物素标记聚丙烯酰胺的 α-唾液酸基团的结合。这些聚合物抑制流感病毒与红细胞粘附的功效（通过血凝试验测量）与聚合物对病毒表面的结合亲和力直接相关：聚合物抑制剂和单体α-甲基唾液酸苷，在分子量范围窄的聚合多价抑制剂的部分中，以及在通过共聚或改性预制聚合物链制备的聚合抑制剂中，所有这些都与抑制剂对表面的亲和力差异有关。病毒。根据溶液中的总唾液酸基团，所研究的聚合物抑制剂对病毒表面的亲和力比 α-甲基唾液酸苷高 103 至 >106。位阻稳定在机理中的作用...
• High polymers containing nicotinic acid, process for their preparation
  申请人：——

  公开号：US04169923A1

  公开（公告）日：1979-10-02

  Polymers having molecular weight between 1,000 and 1,500,000 characterized in that they contain radicals of nicotinic acid bound to the macromolecular structure by covalent bonds that are gradually hydrolyzed in biological environment by setting free nicotinic acid and non-toxic polymer residues.

  具有分子量在1,000至1,500,000之间的聚合物，其特征在于它们包含烟酸基团，这些基团通过共价键结合到大分子结构上，并在生物环境中逐渐水解，释放出烟酸和无毒聚合物残留物。
• Method for immobilizing biologic molecules on solid surfaces
  申请人：Chiari Marcella

  公开号：US20060141464A1

  公开（公告）日：2006-06-29

  The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support.

  该发明提供了一种将生物分子如核酸、肽和蛋白质固定到玻璃或塑料固体支撑物表面的方法。
• BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20150267196A1

  公开（公告）日：2015-09-24

  A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition.

  一种组合物包括可生物降解的水凝胶，该水凝胶包括水凝胶形成基础聚合物和多种生理降解的酯键、酰胺键、偶氮-炔环加成键、丙烯酸基-硫醇键、脲键和/或甲基丙烯酸基-硫醇键，以及与多核苷酸耦合的聚合分子；和多核苷酸。在生理条件下，该多核苷酸以空间和/或时间受控或预定的方式从该组合物中释放出来。