[Au{P(t-Bu)3}(S2CN(C2H5)2)]

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [Au{P(t-Bu)3}(S2CN(C2H5)2)]
• 英文别名: N,N-diethylcarbamodithioate;gold(1+);tritert-butylphosphane
• 化学式: C₁₇H₃₇AuNPS₂
• 分子量: 547.56
• InChiKey: KGTXLVGXXZYEEU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  6.02
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯代三叔丁基磷化金(I) 、 sodium diethyldithiocarbamate trihydrate 以 乙醇 、 二氯甲烷 为溶剂， 反应 3.0h， 以95%的产率得到[Au{P(t-Bu)3}(S2CN(C2H5)2)]
  参考文献：
  名称：

  Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

  摘要：

  Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.03.019

文献信息

• GOLD(I) COMPLEXES WITH T-BUTYL PHOSPHINE AND DIALKYL DITHIOCARBAMATE LIGANDS
  申请人：King Abdulaziz City for Science and Technology

  公开号：US20150266909A1

  公开（公告）日：2015-09-24

  Gold(I) complexes of formulae [AuP(t-Bu) 3 }(S 2 CN(CH 3 ) 2 )] (1), and [AuP(t-Bu) 3 }(S 2 CN(C 2 H 5 ) 2 )] (2) have been prepared by the reaction of equimolar amounts of [AuP(t-Bu) 3 }(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.

  已经合成了配方为[AuP(t-Bu)3}(S2CN(CH3)2)] (1)和[AuP(t-Bu)3}(S2CN(C2H5)2)] (2)的金(I)配合物，通过将等摩尔量的[AuP(t-Bu)3}(Cl)]与单水合硫代二甲基氨基甲酸钠和三水合硫代二乙基氨基甲酸钠反应而制备。这两个配合物(1)和(2)具有相同的结构，呈线性几何构型。这些金(I)硫代二氨基甲酸盐配合物在体外对A549（人肺癌）、HeLa（人宫颈癌）和MCF7（人乳腺癌）细胞系表现出细胞毒活性。