N-cinnamylphenothiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: N-cinnamylphenothiazine
• 英文别名: 10-[(E)-3-phenylprop-2-enyl]phenothiazine
• 化学式: C₂₁H₁₇NS
• 分子量: 315.439
• InChiKey: IAHBDTLPBAXGDL-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吩噻嗪 、 3-苯基丙-2-烯-1-醇 在 titanium(IV) isopropylate 、 palladium diacetate 、 三苯基膦 作用下， 以 苯 为溶剂， 反应 3.0h， 以70%的产率得到N-cinnamylphenothiazine
  参考文献：
  名称：

  直接使用烯丙醇对酸性和亲核性较小的苯胺进行钯催化的烯丙基化。

  摘要：

  通过在异丙氧基钛（IV）和4 A分子筛的存在下进行反应，可以加快钯络合物在烯丙醇中CO键的直接活化。酸性和较少亲核性的苯胺，如二苯胺，吩噻嗪，4-氰基苯胺和硝基苯胺，在钯催化下使用烯丙醇作为烯丙基化试剂可以有效地烯丙基化。

  DOI：

  10.1248/cpb.53.1266

文献信息

• ALPHA-SYNUCLEIN LIGANDS
  申请人：Washington University

  公开号：US20170189566A1

  公开（公告）日：2017-07-06

  The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).

  本发明通常涉及作为α-突触核蛋白配体有用的各种化合物。该发明进一步涉及使用这些化合物及其放射标记类似物用于检测突触核蛋白病，包括帕金森病（PD）的方法。
• Palladium(0)-Catalyzed Allylation of Highly Acidic and Nonnucleophilic Anilines. The Origin of Stereochemical Scrambling When Using Allylic Carbonates
  作者：Marcial Moreno-Mañas、Lurdes Morral、Roser Pleixats

  DOI：10.1021/jo980209j

  日期：1998.9.1

  nitroanilines are efficiently allylated under palladium catalysis using allyl carbonates as allylating reagents. A stereochemical study of the reactions of ethyl cis-5-methyl-2-cyclohexenylcarbonate with 4-nitro- and 2,4-dinitroaniline was performed. Bidentate phosphines as stabilizing ligands gave clean retention of configuration whereas triphenylphosphine permitted cis-trans isomerization of the allylic carbonate

  酸性苯胺（如二苯胺，吩噻嗪和硝基苯胺）在钯催化下使用碳酸烯丙酯作为烯丙基化试剂可以有效地烯丙基化。进行了立体化学研究顺式5-甲基-2-环己烯基碳酸乙酯与4-硝基和2,4-二硝基苯胺的反应。二齿膦作为稳定的配体，使构型保持清晰，而三苯膦则允许烯丙基碳酸酯的顺反异构化，烯丙基化反应发生在Curtin-Hammet预平衡条件下。
• Palladium-Catalyzed Allylation of Acidic and Less Nucleophilic Anilines Using Allylic Alcohols Directly
  作者：Yi-Chun Hsu、Kim-Hong Gan、Shyh-Chyun Yang

  DOI：10.1248/cpb.53.1266

  日期：——

  activation of C-O bonds in allylic alcohols by palladium complexes has been accelerated by carrying out the reactions in the presence of titanium(IV) isoproxide and 4 A molecular sieves. The acidic and less nucleophilic anilines such as diphenylamine, phenothiazine, 4-cyanoaniline, and nitroanilines are efficiently allylated under palladium catalysis using allylic alcohols as allylating reagents.

  通过在异丙氧基钛（IV）和4 A分子筛的存在下进行反应，可以加快钯络合物在烯丙醇中CO键的直接活化。酸性和较少亲核性的苯胺，如二苯胺，吩噻嗪，4-氰基苯胺和硝基苯胺，在钯催化下使用烯丙醇作为烯丙基化试剂可以有效地烯丙基化。
• Alpha-synuclein ligands
  申请人：Washington University

  公开号：US10300155B2

  公开（公告）日：2019-05-28

  The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).

  本发明一般涉及可用作α-突触核蛋白配体的各种化合物。本发明还涉及使用这些化合物及其放射性标记类似物检测突触核蛋白病（包括帕金森病）的方法。
• Direct palladium/carboxylic acid-catalyzed allylation of anilines with allylic alcohols in water
  作者：Shyh-Chyun Yang、Yi-Chun Hsu、Kim-Hong Gan

  DOI：10.1016/j.tet.2006.02.035

  日期：2006.4

  The direct activation of C-O bonds in allylic alcohols in water as a suspension medium by palladium complexes has been accelerated by carrying out the reactions in the presence of a carboxylic acid. The palladium-catalyzed allylation of anilines using allylic alcohols directly gave allylic anilines in good yields. (c) 2006 Elsevier Ltd. All rights reserved.