bis-((R)-2-amino-3-hydroxy-3,3-diphenyl propyl)disulfide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-((R)-2-amino-3-hydroxy-3,3-diphenyl propyl)disulfide
• 英文别名: (2R)-2-amino-3-[[(2R)-2-amino-3-hydroxy-3,3-diphenylpropyl]disulfanyl]-1,1-diphenylpropan-1-ol
• 化学式: C₃₀H₃₂N₂O₂S₂
• 分子量: 516.728
• InChiKey: OYBCQKMDXYLFIG-NSOVKSMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-胱氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 作用下， 以 乙醚 为溶剂， 反应 24.0h， 生成 bis-((R)-2-amino-3-hydroxy-3,3-diphenyl propyl)disulfide
  参考文献：
  名称：

  Enantioselective reduction of prochiral ketones catalyzed by new (R)-4-(phenylmercapto)methyl-5,5-diphenyl-1,3,2-oxazaborolidine and bis-[(R,R)-5,5-diphenyl-1,3,2-oxazaborolidine methyl]disulfide from l-cystine

  摘要：

  Two new optically active beta-amino alcohols 1 and 2 were prepared from L-cystine. The in situ formed chiral oxazaborolidines have been used in the enantioselective catalytic homogeneous borane reduction of prochiral ketones and diketones. The chiral secondary alcohols are obtained with moderate to good enantiomeric excess. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00212-7

文献信息

• Enantioselective reduction of prochiral ketones catalyzed by new (R)-4-(phenylmercapto)methyl-5,5-diphenyl-1,3,2-oxazaborolidine and bis-[(R,R)-5,5-diphenyl-1,3,2-oxazaborolidine methyl]disulfide from l-cystine
  作者：Xingshu Li、Rugang Xie

  DOI：10.1016/s0957-4166(97)00212-7

  日期：1997.7

  Two new optically active beta-amino alcohols 1 and 2 were prepared from L-cystine. The in situ formed chiral oxazaborolidines have been used in the enantioselective catalytic homogeneous borane reduction of prochiral ketones and diketones. The chiral secondary alcohols are obtained with moderate to good enantiomeric excess. (C) 1997 Elsevier Science Ltd.