Ragaglitazar L-arginine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: Ragaglitazar L-arginine
• 英文别名: 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid L-arginine salt；ragaglitazar L-arginine salt；(2S) 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxy propanoic acid L-arginine salt；(L)-arginine (2S)-2-ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate；[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]azanium;(2S)-2-ethoxy-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]propanoate
• 化学式: C₆H₁₄N₄O₂*C₂₅H₂₅NO₅
• 分子量: 593.68
• InChiKey: LCBJEJLDEGRRPF-OMTJCYKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  196
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  L-精氨酸 、 ragaglitazar 以 水 、 丙酮 为溶剂， 反应 24.0h， 以1.29 g的产率得到Ragaglitazar L-arginine
  参考文献：
  名称：

  Polymorphic Study of l-Arginine Salt of Ragaglitazar (DRF-2725)

  摘要：

  In the manufacturing process, during our attempts to get a suitable polymorph by reacting the aqueous solution of L-arginine with 3-[4-[2-(phenoxazin-10-yl) ethoxy]phenyl]-2-ethoxypropanoic acid (ragaglitazar) in different solvents, we have encountered various polymorphic modifications. These forms were characterized using differential scanning calorimetry (DSC), thermogravimetric analysis TGA, and powder X-ray diffraction (PXRD) techniques. The polymorphic forms of arginine salt of ragaglitazar (1) defined below is known to lower sugar level, lower total cholesterol (TC); increase high-density lipoprotein (HDL) and decrease low-density lipoprotein (LDL), which have a beneficial effect on type-II diabetes, coronary heart disease, and atherosclerosis.

  DOI：

  10.1021/op030025t

文献信息

• [EN] PROCESS FOR THE PREPARATION OF ANTIDIABETIC PHENOXAZINE COMPOUNDS<br/>[FR] PROCEDE DE PREPARATION DE COMPOSES DE PHENOXAZINE ANTIDIABETIQUE
  申请人：REDDYS LAB LTD DR

  公开号：WO2004063178A1

  公开（公告）日：2004-07-29

  A process for the preparation of compound of the formula (I), wherein R1 represents (C1-C6) alkyl group via a compound of formula (III).

  一种制备化合物（I）的方法，其中R1代表（C1-C6）烷基基团，通过化合物的公式（III）。
• Polymorphic Study of <scp>l</scp>-Arginine Salt of Ragaglitazar (DRF-2725)
  作者：S. Raju、P. Rajender Kumar、K. Vyas、D. Srinivas Rao、M. R. Sarma、S. Vishnuvardhan Reddy、M. Nirmala、G. Om Reddy

  DOI：10.1021/op030025t

  日期：2003.11.1

  In the manufacturing process, during our attempts to get a suitable polymorph by reacting the aqueous solution of L-arginine with 3-[4-[2-(phenoxazin-10-yl) ethoxy]phenyl]-2-ethoxypropanoic acid (ragaglitazar) in different solvents, we have encountered various polymorphic modifications. These forms were characterized using differential scanning calorimetry (DSC), thermogravimetric analysis TGA, and powder X-ray diffraction (PXRD) techniques. The polymorphic forms of arginine salt of ragaglitazar (1) defined below is known to lower sugar level, lower total cholesterol (TC); increase high-density lipoprotein (HDL) and decrease low-density lipoprotein (LDL), which have a beneficial effect on type-II diabetes, coronary heart disease, and atherosclerosis.